| Gene Symbol |
CACNG5
|
| Entrez Gene |
27091
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, gamma subunit 5
|
| Other Description |
TARP gamma-5|neuronal voltage-gated calcium channel gamma-5 subunit|transmembrane AMPAR regulatory protein gamma-5|voltage-dependent calcium channel gamma-5 subunit
|
| Swissprots |
Q9UF02 Q9UHM3 Q8WXS7 Q547R3 A8K2A6
|
| Accessions |
AAF03089 CAC36508 EAW89018 EAW89019 Q9UF02 AF148220 AAF00132 AF361351 AAL50046 AF458898 AAM00595 AK290171 BAF82860 BC101607 AAI01608 BC101633 AAI01634 XM_011524613 XP_011522915 NM_145811 NP_665810 NM_014404
|
| Function |
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|
![Western Blot: CACNG5 Overexpression Lysate (Adult Normal) [NBP2-05372] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CACNG5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10518_CACNG5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05372-img0001.jpg)