Gene Symbol | CACNG5 |
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Entrez Gene | 27091 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 5 |
Other Description | TARP gamma-5|neuronal voltage-gated calcium channel gamma-5 subunit|transmembrane AMPAR regulatory protein gamma-5|voltage-dependent calcium channel gamma-5 subunit |
Swissprots | Q9UF02 Q9UHM3 Q8WXS7 Q547R3 A8K2A6 |
Accessions | AAF03089 CAC36508 EAW89018 EAW89019 Q9UF02 AF148220 AAF00132 AF361351 AAL50046 AF458898 AAM00595 AK290171 BAF82860 BC101607 AAI01608 BC101633 AAI01634 XM_011524613 XP_011522915 NM_145811 NP_665810 NM_014404 |
Function | Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP γ5 CRISPR/Cas9 KO Plasmid (h) - sc-411955 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 HDR Plasmid (h) - sc-411955-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 Double Nickase Plasmid (h) - sc-411955-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 Double Nickase Plasmid (h2) - sc-411955-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 CRISPR Activation Plasmid (h) - sc-411955-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 CRISPR Activation Plasmid (h2) - sc-411955-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 Lentiviral Activation Particles (h) - sc-411955-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 Lentiviral Activation Particles (h2) - sc-411955-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 siRNA (h) - sc-93924 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 shRNA Plasmid (h) - sc-93924-SH from Santa Cruz Biotechnology
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L-type Ca ++ CP γ5 shRNA (h) Lentiviral Particles - sc-93924-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5277 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5277 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01634 from Sigma-Aldrich
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CACNG5 siRNA (Human) - CRH8958 from Cohesion Biosciences
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CACNG5 RNAi - H00027091-R01 from Novus Biologicals
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CACNG5 RNAi - H00027091-R02 from Novus Biologicals
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CACNG5 - MBS8235155 from MyBioSource
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Human CACNG5 siRNA - orb269460 from Biorbyt
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CACNG5 shRNA Plasmid (Human) - CHH8958 from Cohesion Biosciences
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