RNF34

Gene Symbol	RNF34
Entrez Gene	80196
Alt Symbol	CARP-1, CARP1, RFI, RIF, RIFF, hRFI
Species	Human
Gene Type	protein-coding
Description	ring finger protein 34, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF34|FYVE-RING finger protein MOMO|RING finger protein RIFF|caspase regulator CARP1|caspases-8 and -10-associated RING finger protein 1|human RING finger homologous to inhibitor of apoptosis protein
Swissprots	B7Z933 Q969K3 Q8NG47 Q9H6W8
Accessions	EAW98262 EAW98263 EAW98264 Q969K3 AB084914 BAC11802 AF306709 AAK51328 AK024957 AK025439 BAB15132 AK096994 AK130355 AK225285 AK304366 BAH14169 AL557811 AY098934 AAM29180 BC007826 AAH07826 BC039029 BC046174 BI559962 BT007283 AAP35947 CR457342 CAG33623 DA887995 DB242808 NM_001256858 NP_001243787 NM_025126 NP_079402 NM_194271 NP_919247
Function	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, throu
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15069192}; Peripheral membrane protein {ECO:0000305}. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus {ECO:0000269|PubMed:22064484}. Nucleus speckle {ECO:0000269|PubMed:12118383}. Cytoplasm, cytosol {ECO:0000269|PubMed:15069192}.
Tissue Specificity	Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

hRIF (D-14) - sc-74662 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RNF34 antibody - ab4363 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-RNF34 antibody - ab129687 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, AP) - LS-C217223 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, APC) - LS-C217224 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, Biotin) - LS-C217225 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, FITC) - LS-C217226 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, Azide-free, HRP) - LS-C217227 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa143-192) - LS-C110483 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311, PE) - LS-C217229 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa200-250) - LS-C289665 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa282-311) - LS-C324744 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa283-311) - LS-C162659 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa1-373) IHC-plus™ - LS-B132 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RNF34 Antibody (aa3-14) IHC-plus™ - LS-B2995 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-RNF34 Antibody (aa299-311) - LS-C55407 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-RNF34 Antibody (aa1-373) - LS-C131928 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RNF34 Antibody - NBP1-77904 from Novus Biologicals Prices $369.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RNF34 Antibody - NB100-1202 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

RNF34 Antibody - H00080196-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

RNF34 Antibody - NBP1-77903 from Novus Biologicals Prices $399.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

RNF34 Antibody - NB100-93460 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

RNF34 Antibody - H00080196-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

RNF34 Polyclonal Antibody - bs-9242R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF34 (36-50) antibody produced in rabbit - SAB1101892 from Sigma-Aldrich Prices $328.50 Sizes 200 µl Host Rabbit Clonality Polyclonal

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