RNF34

Gene Symbol RNF34
Entrez Gene 80196
Alt Symbol CARP-1, CARP1, RFI, RIF, RIFF, hRFI
Species Human
Gene Type protein-coding
Description ring finger protein 34, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase RNF34|FYVE-RING finger protein MOMO|RING finger protein RIFF|caspase regulator CARP1|caspases-8 and -10-associated RING finger protein 1|human RING finger homologous to inhibitor of apoptosis protein
Swissprots B7Z933 Q969K3 Q8NG47 Q9H6W8
Accessions EAW98262 EAW98263 EAW98264 Q969K3 AB084914 BAC11802 AF306709 AAK51328 AK024957 AK025439 BAB15132 AK096994 AK130355 AK225285 AK304366 BAH14169 AL557811 AY098934 AAM29180 BC007826 AAH07826 BC039029 BC046174 BI559962 BT007283 AAP35947 CR457342 CAG33623 DA887995 DB242808 NM_001256858 NP_001243787 NM_025126 NP_079402 NM_194271 NP_919247
Function E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, throu
Subcellular Location Cell membrane {ECO:0000269|PubMed:15069192}; Peripheral membrane protein {ECO:0000305}. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus {ECO:0000269|PubMed:22064484}. Nucleus speckle {ECO:0000269|PubMed:12118383}. Cytoplasm, cytosol {ECO:0000269|PubMed:15069192}.
Tissue Specificity Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192}.

hRIF CRISPR/Cas9 KO Plasmid (h) - sc-413358 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF HDR Plasmid (h) - sc-413358-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF Double Nickase Plasmid (h) - sc-413358-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF Double Nickase Plasmid (h2) - sc-413358-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF CRISPR Activation Plasmid (h) - sc-413358-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF CRISPR Activation Plasmid (h2) - sc-413358-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF Lentiviral Activation Particles (h) - sc-413358-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF Lentiviral Activation Particles (h2) - sc-413358-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hRIF siRNA (h) - sc-75301 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

hRIF shRNA Plasmid (h) - sc-75301-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

hRIF shRNA (h) Lentiviral Particles - sc-75301-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF34 RNAi - H00080196-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF34 RNAi - H00080196-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU074201 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18432 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18432 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12323 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12323

RNF34 siRNA (Human) - CRJ2794 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF34 - MBS8207168 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF34 (NM_194271.2) - SHH397300 from Creative biogene

Category siRNA
Species Reactivities Human

RNF34 shRNA Plasmid (Human) - CHJ2794 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF34 miRNA 3'UTR clone - MiUTR3H-09898 from Creative biogene

Species Reactivities Human

RNF34 miRNA 3'UTR clone - MiUTR3H-09899 from Creative biogene

Species Reactivities Human
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