RNF34

Gene Symbol	RNF34
Entrez Gene	80196
Alt Symbol	CARP-1, CARP1, RFI, RIF, RIFF, hRFI
Species	Human
Gene Type	protein-coding
Description	ring finger protein 34, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF34|FYVE-RING finger protein MOMO|RING finger protein RIFF|caspase regulator CARP1|caspases-8 and -10-associated RING finger protein 1|human RING finger homologous to inhibitor of apoptosis protein
Swissprots	B7Z933 Q969K3 Q8NG47 Q9H6W8
Accessions	EAW98262 EAW98263 EAW98264 Q969K3 AB084914 BAC11802 AF306709 AAK51328 AK024957 AK025439 BAB15132 AK096994 AK130355 AK225285 AK304366 BAH14169 AL557811 AY098934 AAM29180 BC007826 AAH07826 BC039029 BC046174 BI559962 BT007283 AAP35947 CR457342 CAG33623 DA887995 DB242808 NM_001256858 NP_001243787 NM_025126 NP_079402 NM_194271 NP_919247
Function	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, throu
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15069192}; Peripheral membrane protein {ECO:0000305}. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus {ECO:0000269|PubMed:22064484}. Nucleus speckle {ECO:0000269|PubMed:12118383}. Cytoplasm, cytosol {ECO:0000269|PubMed:15069192}.
Tissue Specificity	Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF34 full length protein - ab164217 from Abcam Category Protein Source Wheat germ Species Human

Human RNF34 full length protein - ab176063 from Abcam Category Protein Source E. coli Species Human

RNF34 Antibody Blocking Peptide - LS-E4336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF34 Antibody Blocking Peptide - LS-E14601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF34 Antibody Blocking Peptide - LS-E25516 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF34 Antibody Blocking Peptide - LS-E26725 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF34 Recombinant Protein - H00080196-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RNF34 Protein - NBP2-23440 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

RNF34-Antibody-C-term-Blocking-Peptide - BP16633b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF34/RFI (internal) blocking peptide - GTX88725-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

RNF34/RFI (N Terminus) blocking peptide - GTX89815-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

RNF34 Immunizing peptide - orb16368 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

RNF34 Blocking Peptide - 33R-5504 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF34 protein (His tag) - 80R-3552 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

RNF34 Peptide - AC21-0344-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF34 Peptide - AC21-1563-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RFI / RNF34 (1-373, His-tag) - AR51239PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

RFI / RNF34 (1-373, His-tag) - AR51239PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

RFI / RNF34 - H00080196-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RFI / RNF34 - H00080196-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF34, 1-373aa, Human, His tag, E.coli - 01-P2419 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

RFI Peptide - 46-284P from ProSci Category Peptide

RFI Peptide - 46-283P from ProSci Category Peptide Species Human

RNF34 fusion protein - ag0982 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RNF34, 1-373aa, Human, His tag, E.coli - GWB-L34226 from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Species Human

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