FFAR2

Gene Symbol	FFAR2
Entrez Gene	2867
Alt Symbol	FFA2R, GPR43
Species	Human
Gene Type	protein-coding
Description	free fatty acid receptor 2
Other Description	G protein-coupled receptor 43|G-protein coupled receptor 43|free fatty acid activated receptor 2
Swissprots	O15552 Q4VBL5 Q4VAZ3 Q4VAZ5 B0M0J9
Accessions	AAB67886 AAB86713 ABY87913 CAJ33694 O15552 AB378083 BAH86809 AX810701 BC095535 AAH95535 BC096198 AAH96198 BC096199 AAH96199 BC096200 AAH96200 BC096201 AAH96201 CA309917 CK819813 NM_005306 NP_005297
Function	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fa
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}.
Tissue Specificity	Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12684041}.
Top Pathways	cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPR43 (Y-15) - sc-28420 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GPR43 (S-15) - sc-28421 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GPR43 (H-120) - sc-32906 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GPR43 (C-20) - sc-28423 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-GPCR GPR43 antibody - ab124272 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPCR GPR43 antibody - ab118449 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPCR GPR43 antibody - ab131003 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (Extracellular Domain) IHC-plus™ - LS-A6600 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (Extracellular Domain) IHC-plus™ - LS-A6599 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, AP) - LS-C214193 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, APC) - LS-C214194 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, Biotin) - LS-C214195 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, Azide-free, HRP) - LS-C214196 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, FITC) - LS-C214197 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315, PE) - LS-C214199 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa286-315) IHC-plus™ - LS-B9101 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa285-315) - LS-C329549 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (C-Terminus) IHC-plus™ - LS-A6598 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (aa271-320) IHC-plus™ - LS-B5986 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1578 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (Internal) IHC-plus™ - LS-A1586 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FFAR2 / GPR43 Antibody (C-Terminus) - LS-C151906 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

FFAR2/GPR43 Antibody - NBP1-02394 from Novus Biologicals Prices $329.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

FFAR2/GPR43 Antibody - NLS6599 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

FFAR2/GPR43 Antibody - NBP1-02357 from Novus Biologicals Prices $329.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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