| Gene Symbol | FFAR2 |
|---|---|
| Entrez Gene | 2867 |
| Alt Symbol | FFA2R, GPR43 |
| Species | Human |
| Gene Type | protein-coding |
| Description | free fatty acid receptor 2 |
| Other Description | G protein-coupled receptor 43|G-protein coupled receptor 43|free fatty acid activated receptor 2 |
| Swissprots | O15552 Q4VBL5 Q4VAZ3 Q4VAZ5 B0M0J9 |
| Accessions | AAB67886 AAB86713 ABY87913 CAJ33694 O15552 AB378083 BAH86809 AX810701 BC095535 AAH95535 BC096198 AAH96198 BC096199 AAH96199 BC096200 AAH96200 BC096201 AAH96201 CA309917 CK819813 NM_005306 NP_005297 |
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fa |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}. |
| Tissue Specificity | Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12684041}. |
| Top Pathways | cAMP signaling pathway |
GPR43 CRISPR/Cas9 KO Plasmid (h) - sc-401858 from Santa Cruz Biotechnology
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GPR43 HDR Plasmid (h) - sc-401858-HDR from Santa Cruz Biotechnology
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GPR43 Double Nickase Plasmid (h) - sc-401858-NIC from Santa Cruz Biotechnology
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GPR43 Double Nickase Plasmid (h2) - sc-401858-NIC-2 from Santa Cruz Biotechnology
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GPR43 CRISPR Activation Plasmid (h) - sc-401858-ACT from Santa Cruz Biotechnology
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GPR43 CRISPR Activation Plasmid (h2) - sc-401858-ACT-2 from Santa Cruz Biotechnology
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GPR43 Lentiviral Activation Particles (h) - sc-401858-LAC from Santa Cruz Biotechnology
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GPR43 Lentiviral Activation Particles (h2) - sc-401858-LAC-2 from Santa Cruz Biotechnology
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GPR43 siRNA (h) - sc-77339 from Santa Cruz Biotechnology
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GPR43 shRNA Plasmid (h) - sc-77339-SH from Santa Cruz Biotechnology
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GPR43 shRNA (h) Lentiviral Particles - sc-77339-V from Santa Cruz Biotechnology
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FFAR2/GPR43 RNAi - H00002867-R02 from Novus Biologicals
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MISSION® esiRNA - EHU023381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8636 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8636 from Sigma-Aldrich
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FFAR2 siRNA (Human) - CRH1925 from Cohesion Biosciences
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FFAR2 - MBS8225013 from MyBioSource
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GPR43 CRISPR/Cas9 KO Plasmid (h2) - sc-401858-KO-2 from Santa Cruz Biotechnology
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GPR43 HDR Plasmid (h2) - sc-401858-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FFAR2 (NM_005306.2) - SHH294241 from Creative biogene
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Human FFAR2 siRNA - orb262427 from Biorbyt
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FFAR2 shRNA Plasmid (Human) - CHH1925 from Cohesion Biosciences
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FFAR2 miRNA 3'UTR clone - MiUTR4H-TG03522 from Creative biogene
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