FFAR2
| Gene Symbol | FFAR2 |
|---|---|
| Entrez Gene | 2867 |
| Alt Symbol | FFA2R, GPR43 |
| Species | Human |
| Gene Type | protein-coding |
| Description | free fatty acid receptor 2 |
| Other Description | G protein-coupled receptor 43|G-protein coupled receptor 43|free fatty acid activated receptor 2 |
| Swissprots | O15552 Q4VBL5 Q4VAZ3 Q4VAZ5 B0M0J9 |
| Accessions | AAB67886 AAB86713 ABY87913 CAJ33694 O15552 AB378083 BAH86809 AX810701 BC095535 AAH95535 BC096198 AAH96198 BC096199 AAH96199 BC096200 AAH96200 BC096201 AAH96201 CA309917 CK819813 NM_005306 NP_005297 |
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fa |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18801738}; Multi-pass membrane protein {ECO:0000269|PubMed:18801738}. |
| Tissue Specificity | Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12684041}. |
| Top Pathways | cAMP signaling pathway |
Human GPCR GPR43 full length protein - ab152436 from Abcam
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E6004 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E28335 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E28340 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E23732 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E29144 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E29145 from LifeSpan Bioscience
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FFAR2 / GPR43 Antibody Blocking Peptide - LS-E29146 from LifeSpan Bioscience
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Recombinant Human FFAR2/GPR43 Protein - H00002867-P01 from Novus Biologicals
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FFAR2-Antibody-C-term-Blocking-Peptide - BP18578b from Abgent, a WuXi AppTec company
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FFAR2 - H00002867-G01 from Acris Antibodies
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FFAR2 - H00002867-P01 from Acris Antibodies
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FFAR2 - H00002867-P01-10 from Acris Antibodies
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FFAR2 - H00002867-P01-25 from Acris Antibodies
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FFAR2 - H00002867-Q01-10 from Acris Antibodies
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FFAR2 - H00002867-Q01-25 from Acris Antibodies
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FFAR2 Control Peptide - AP06989CP-N from Acris Antibodies
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FFAR2 Control Peptide - SP4226CP from Acris Antibodies
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FFAR2 fusion protein - ag16367 from Proteintech Group
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Recombinant Free Fatty Acid Receptor 2 (FFAR2) - RPC949Mu01 from Uscn Life Science Inc.
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Recombinant Free Fatty Acid Receptor 2 (FFAR2) - RPC949Mu02 from Uscn Life Science Inc.
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ChemiSCREEN™ Membrane Preparation Recombinant Human GPR43 Free Fatty Acid Receptor - HTS063M from EMD Millipore
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FFAR2/GPR43 Recombinant Protein - H00002867-G01 from Novus Biologicals
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GPR43 Blocking Peptide - abx161854 from Abbexa
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FFAR2 Peptide, Human - M34GP05684H from Creative Peptides
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