| Gene Symbol |
PEMT
|
| Entrez Gene |
10400
|
| Alt Symbol |
PEAMT, PEMPT, PEMT2, PNMT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylethanolamine N-methyltransferase
|
| Other Description |
-
|
| Swissprots |
Q9UBM1 B4DY41 D3DXC3 Q6IAQ5 Q86VL3 Q9BW86 Q9Y6V9 A8MZ66 Q9UHY6
|
| Accessions |
AAK19172 ACB21050 EAW55700 EAW55701 EAW55702 Q9UBM1 AB029821 BAA82407 AF044214 AAQ13425 AF113126 AAF14867 AF176806 AAD53291 AF176807 AAD53292 AK302251 BAG63603 BC000557 AAH00557 BC050593 AAH50593 BM011377 CR457099 CAG33380 HQ448599 ADQ33077 XM_006721418 XP_006721481 NM_001267551 NP_001254480 NM_001267552 NP_001254481 NM_007169 NP_009100 NM_148172 NP_680477 NM_148173 NP_680478
|
| Function |
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
|
| Subcellular Location |
Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.
|
| Top Pathways |
Glycerophospholipid metabolism
|
