| Gene Symbol |
PIRT
|
| Entrez Gene |
644139
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-interacting regulator of transient receptor potential channels
|
| Other Description |
phosphoinositide-interacting protein|phosphoinositide-interacting regulator of TRPV1
|
| Swissprots |
P0C851 B7Z648
|
| Accessions |
EAW89989 P0C851 AK021549 AK299808 BAH13134 AK300493 BAG62207 DC332889 NM_001101387 NP_001094857
|
| Function |
Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5- bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
![Western Blot: PIRT Overexpression Lysate (Adult Normal) [NBP2-09337] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PIRT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10378_PIRT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09337-img0001.jpg)