Gene Symbol | PIRT |
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Entrez Gene | 644139 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | phosphoinositide-interacting regulator of transient receptor potential channels |
Other Description | phosphoinositide-interacting protein|phosphoinositide-interacting regulator of TRPV1 |
Swissprots | P0C851 B7Z648 |
Accessions | EAW89989 P0C851 AK021549 AK299808 BAH13134 AK300493 BAG62207 DC332889 NM_001101387 NP_001094857 |
Function | Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5- bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
PIRT CRISPR/Cas9 KO Plasmid (h) - sc-416125 from Santa Cruz Biotechnology
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PIRT HDR Plasmid (h) - sc-416125-HDR from Santa Cruz Biotechnology
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PIRT Double Nickase Plasmid (h) - sc-416125-NIC from Santa Cruz Biotechnology
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PIRT Double Nickase Plasmid (h2) - sc-416125-NIC-2 from Santa Cruz Biotechnology
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PIRT CRISPR Activation Plasmid (h) - sc-416125-ACT from Santa Cruz Biotechnology
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PIRT CRISPR Activation Plasmid (h2) - sc-416125-ACT-2 from Santa Cruz Biotechnology
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PIRT Lentiviral Activation Particles (h) - sc-416125-LAC from Santa Cruz Biotechnology
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PIRT Lentiviral Activation Particles (h2) - sc-416125-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU226491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16834 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16834 from Sigma-Aldrich
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PIRT siRNA (Human) - CRJ8482 from Cohesion Biosciences
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shRNA set against Human PIRT (NM_001101387.1) - SHH376120 from Creative biogene
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PIRT shRNA Plasmid (Human) - CHJ8482 from Cohesion Biosciences
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PIRT miRNA 3'UTR clone - MiUTR4H-TG12146 from Creative biogene
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