MOB1A

Gene Symbol MOB1A
Entrez Gene 55233
Alt Symbol C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B
Species Human
Gene Type protein-coding
Description MOB kinase activator 1A
Other Description MOB1 Mps One Binder homolog A|MOB1, Mps One Binder kinase activator-like 1B|mob1 alpha|mob1 homolog 1B|mps one binder kinase activator-like 1B
Swissprots Q9H8S9 Q9NVE2 Q9H3T5 Q53S34 Q9HAI0
Accessions AAX93060 CAG44585 EAW99695 EAW99696 Q9H8S9 AB016839 BAB19058 AJ577474 CAE12093 AK001650 BAA91810 AK021657 BAB13868 AK023321 BAB14525 BC003398 AAH03398 HQ448722 ADQ33200 XM_011532947 XP_011531249 XM_011532948 XP_011531250 XM_011532949 XP_011531251 NM_018221 NP_060691
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.
Tissue Specificity Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
Top Pathways Hippo signaling pathway

Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb - 8699 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2F10
Western blot analysis of extracts from MCF7 cells, either untreated (-) or treated (+) with H 2 O 2 (2.5 mM, 30 min) and Ramos cells, either untreated (-) or treated (+) with λ phosphatase, using Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb (upper) and MOB1 Antibody #3863 (lower).

Phospho-MOB1 (Thr12) (D2E3) Rabbit mAb - 8843 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E3
Western blot analysis of extracts from MCF7 cells, untreated or H 2 O 2 -treated (2.5 mM, 30 min), using Phospho-MOB1 (Thr12) (D2E3) Rabbit mAb (upper) and MOB1 Antibody #3863 (lower).

MOB1 (E1N9D) Rabbit mAb - 13730 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1N9D
Western blot analysis of extracts from various cell lines using MOB1 (E1N9D) Rabbit mAb.

MOB1 Antibody - 3863 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MOB1 Antibody.

MOB1A (H-64) - sc-367738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MOB1A (H-64): sc-367738. Western blot analysis of MOB1A expression in Ramos (A), A2058 (B), K-562 (C) and Jurkat (D) whole cell lysates.

MOB1A (G-7) - sc-393212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOB1A (G-7): sc-393212. Western blot analysis of MOB1A expression in K-562 (A), T98G (B), Ramos (C), Raji (D) and Jurkat (E) whole cell lysates.

MOB1A/B (N-16) - sc-161867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOB1A/B (N-16): sc-161867. Western blot analysis of MOBKL1B expression in non-transfected: sc-117752 (A) and human MOBKL1B transfected: sc-371897 (B) 293T whole cell lysates.

Anti-MOBK1B antibody - ab110778 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MOBK1B antibody (ab110778) at 1 µg/mlLane 1 : Adrenal (Human) Whole Cell Lysate - adult normal tissue (ab29249)Lane 2 : Bone Marrow (Human) Tissue Lysate - adult normal tissueLane 3 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 4 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 5 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 6 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lane 7 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MOBK1B antibody - ab135325 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MOBK1B antibody (ab135325) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-MOBK1B antibody - C-terminal - ab198916 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MOBK1B antibody - C-terminal (ab198916) at 1/200 dilutionLane 1 : A375 cell lysateLane 2 : K562 cell lysateLane 3 : Mouse liver tissue lysateLane 4 : Raji cell lysateLane 5 : Jurkat cell lysateLane 6 : HeLa cell lysateLysates/proteins at 40 µg per lane.

Anti-MOBK1B antibody - Carboxyterminal end - ab91063 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MOBK1B antibody - Carboxyterminal end (ab91063) at 1/50 dilution + A2058 cell line lysates at 12.5 µg

Anti-MOBK1B antibody - N-terminal - ab171300 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MOBK1B antibody - N-terminal (ab171300) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysateLane 2 : 293 cell lysate transiently-transfected with the MOBKL1B geneLysates/proteins at 2 µg per lane.

Anti-MOBK1B antibody - N-terminal - ab199908 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MOBK1B antibody - N-terminal (ab199908) at 1/1000 dilutionLane 1 : mouse thymus total cell extractsLane 2 : Jurkat total cell extracts

Anti-MOB1A Antibody (aa167-216) IHC-plus™ - LS-B11559 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-MOB1A Antibody (aa188-216) - LS-C100567 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MOBKL1B Antibody IHC of formalin-fixed and paraffin-embedded human Prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-MOB1A Antibody (aa81-130) - LS-C205432 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MOB1A antibody Western Blot of Jurkat. Antibody dilution: 1 ug/ml.

Anti-MOB1A Antibody (aa5-33) - LS-C164259 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of MOBKL1B (arrow) using rabbit polyclonal MOBKL1B Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MOBKL1B gene.

MOBKL1B Antibody - NBP2-32051 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MOBKL1B Antibody [NBP2-32051] - Staining of human adrenal gland shows strong cytoplasmic positivity in glandular cells.

Rabbit Anti-C2orf6 Polyclonal Antibody - bs-6549R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-MOBK1B/C2orf6 Polyclonal Antibody, Unconjugated (bs-6549R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

ANTI-MOBKL1B (N-TERM) antibody produced in rabbit - SAB1302416 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MOBKL1B (N-term): <B>Cat. No. SAB1302416</B>: Western blot analysis of MOBKL1B (arrow) using rabbit polyclonal MOBKL1B Antibody (N-term).<BR/><B>Lanes:</B><BR/>1. nontransfected with the MOBKL1B gene<BR/>2.transiently transfected with the MOBKL1B gene

Anti-MOB1A antibody produced in rabbit - SAB4301095 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-MOBKL1B (C-TERM) antibody produced in rabbit - SAB1301169 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>MOBKL1B (C-term): <B>Cat. No. SAB1301169</B>: MOBKL1B in Human prostata carcinoma tissue with MOBKL1B antibody (C-term) at 5 μg/mL.

MOB1A Antibody - C-terminal region (ARP65686_P050) - ARP65686_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MOB1A Antibody - middle region (ARP65687_P050) - ARP65687_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MOBKL1B-Antibody-N-term - AP12884a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of MOBKL1B (arrow) using rabbit polyclonal MOBKL1B Antibody (N-term) (Cat. #AP12884a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MOBKL1B gene.
Search more