MOB1A

Gene Symbol	MOB1A
Entrez Gene	55233
Alt Symbol	C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B
Species	Human
Gene Type	protein-coding
Description	MOB kinase activator 1A
Other Description	MOB1 Mps One Binder homolog A|MOB1, Mps One Binder kinase activator-like 1B|mob1 alpha|mob1 homolog 1B|mps one binder kinase activator-like 1B
Swissprots	Q9H8S9 Q9NVE2 Q9H3T5 Q53S34 Q9HAI0
Accessions	AAX93060 CAG44585 EAW99695 EAW99696 Q9H8S9 AB016839 BAB19058 AJ577474 CAE12093 AK001650 BAA91810 AK021657 BAB13868 AK023321 BAB14525 BC003398 AAH03398 HQ448722 ADQ33200 XM_011532947 XP_011531249 XM_011532948 XP_011531250 XM_011532949 XP_011531251 NM_018221 NP_060691
Function	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.
Tissue Specificity	Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MOBK1B full length protein - ab102026 from Abcam Category Protein Source E. coli Species Human

Human MOBK1B full length protein - ab88401 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

MOB1A Antibody Blocking Peptide - LS-E2020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MOB1A Antibody Blocking Peptide - LS-E8906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MOBKL1B Recombinant Protein - H00055233-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MOBKL1B Protein - NBP1-50950 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

MOBKL1B-Antibody-N-term-Blocking-peptide - BP12884a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MOBKL1B-Antibody-C-term-Blocking-Peptide - BP7379b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MOBKL1B Protein (OPPA00159) - OPPA00159 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human MOBKL1B protein - orb49540 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human MOBKL1B protein - orb168847 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human MOB1A protein - orb246638 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MOBKL1B protein (His tag) - 80R-1625 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Human MOBK1B Protein - abx060049 from Abbexa Category Protein Source Yeast Species Human

MOBKL1B (1-216, His-tag) - AR09806PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

MOBKL1B (1-216, His-tag) - AR09806PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

MOBKL1B - H00055233-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MOBKL1B - H00055233-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MOB1, Mps One Binder Kinase Activator-Like 1B, Human Recombinant - 228-12788-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human MOB1, Mps One Binder Kinase Activator-Like 1B - 228-12788-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human MOB1, Mps One Binder Kinase Activator-Like 1B - 228-12788-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

MOB Kinase Activator 1A, MOB1A, Human, Recombinant - 19-C297 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

MOBKL1B, 1-216aa, Human, His tag, E.coli - 01-2311-1B from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

MOBKL1B fusion protein - ag14889 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MOBKL1B fusion protein - Ag2252 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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