| Gene Symbol |
MOB1A
|
| Entrez Gene |
55233
|
| Alt Symbol |
C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MOB kinase activator 1A
|
| Other Description |
MOB1 Mps One Binder homolog A|MOB1, Mps One Binder kinase activator-like 1B|mob1 alpha|mob1 homolog 1B|mps one binder kinase activator-like 1B
|
| Swissprots |
Q9H8S9 Q9NVE2 Q9H3T5 Q53S34 Q9HAI0
|
| Accessions |
AAX93060 CAG44585 EAW99695 EAW99696 Q9H8S9 AB016839 BAB19058 AJ577474 CAE12093 AK001650 BAA91810 AK021657 BAB13868 AK023321 BAB14525 BC003398 AAH03398 HQ448722 ADQ33200 XM_011532947 XP_011531249 XM_011532948 XP_011531250 XM_011532949 XP_011531251 NM_018221 NP_060691
|
| Function |
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.
|
| Tissue Specificity |
Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
|
| Top Pathways |
Hippo signaling pathway
|