| Gene Symbol |
VAT1
|
| Entrez Gene |
10493
|
| Alt Symbol |
VATI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vesicle amine transport 1
|
| Other Description |
membrane protein of cholinergic synaptic vesicles|synaptic vesicle membrane protein VAT-1 homolog|vesicle amine transport protein 1 homolog (T. californica)
|
| Swissprots |
Q96A39 Q13035 Q99536 B0AZP7 Q9BUT8 A8K345 Q5BKZ7 B4DPX4
|
| Accessions |
AAC37596 EAW60917 EAW60918 Q99536 AK097072 BAG53420 AK290460 BAF83149 AK298536 BAG60736 AK315838 BAF98729 BC001913 AAH01913 BC008725 AAH08725 BC014279 AAH14279 BC015041 AAH15041 BC068489 BC090858 AAH90858 BT007369 AAP36033 HQ258013 ADR82767 U18009 AAA95990 U25779 AAA93230 NM_006373 NP_006364
|
| Function |
Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain. Also expressed in glioblastoma cells. {ECO:0000269|PubMed:19508442}.
|
![Western Blot: VAT1 Overexpression Lysate (Adult Normal) [NBL1-17700] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VAT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5729_VAT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17700-img0002.jpg)