Gene Symbol | VAT1 |
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Entrez Gene | 10493 |
Alt Symbol | VATI |
Species | Human |
Gene Type | protein-coding |
Description | vesicle amine transport 1 |
Other Description | membrane protein of cholinergic synaptic vesicles|synaptic vesicle membrane protein VAT-1 homolog|vesicle amine transport protein 1 homolog (T. californica) |
Swissprots | Q96A39 Q13035 Q99536 B0AZP7 Q9BUT8 A8K345 Q5BKZ7 B4DPX4 |
Accessions | AAC37596 EAW60917 EAW60918 Q99536 AK097072 BAG53420 AK290460 BAF83149 AK298536 BAG60736 AK315838 BAF98729 BC001913 AAH01913 BC008725 AAH08725 BC014279 AAH14279 BC015041 AAH15041 BC068489 BC090858 AAH90858 BT007369 AAP36033 HQ258013 ADR82767 U18009 AAA95990 U25779 AAA93230 NM_006373 NP_006364 |
Function | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
Subcellular Location | Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria. {ECO:0000250}. |
Tissue Specificity | Expressed in brain. Also expressed in glioblastoma cells. {ECO:0000269|PubMed:19508442}. |
VAT1 CRISPR/Cas9 KO Plasmid (h) - sc-405997 from Santa Cruz Biotechnology
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VAT1 HDR Plasmid (h) - sc-405997-HDR from Santa Cruz Biotechnology
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VAT1 Double Nickase Plasmid (h) - sc-405997-NIC from Santa Cruz Biotechnology
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VAT1 Double Nickase Plasmid (h2) - sc-405997-NIC-2 from Santa Cruz Biotechnology
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VAT1 CRISPR Activation Plasmid (h) - sc-405997-ACT from Santa Cruz Biotechnology
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VAT1 CRISPR Activation Plasmid (h2) - sc-405997-ACT-2 from Santa Cruz Biotechnology
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VAT1 Lentiviral Activation Particles (h) - sc-405997-LAC from Santa Cruz Biotechnology
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VAT1 Lentiviral Activation Particles (h2) - sc-405997-LAC-2 from Santa Cruz Biotechnology
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VAT1 siRNA (h) - sc-93942 from Santa Cruz Biotechnology
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VAT1 shRNA Plasmid (h) - sc-93942-SH from Santa Cruz Biotechnology
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VAT1 shRNA (h) Lentiviral Particles - sc-93942-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22646 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22646 from Sigma-Aldrich
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VAT1 siRNA (Human) - CRH7130 from Cohesion Biosciences
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VAT1 - MBS8218642 from MyBioSource
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shRNA set against Human VAT1 (NM_006373.3) - SHH442332 from Creative biogene
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shRNA set against Human VAT1(NM_006373.3) - SHL121726 from Creative biogene
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VAT1 shRNA Plasmid (Human) - CHH7130 from Cohesion Biosciences
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VAT1 miRNA 3'UTR clone - MiUTR1H-11099 from Creative biogene
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