CASC3

Gene Symbol	CASC3
Entrez Gene	22794
Alt Symbol	BTZ, MLN51
Species	Human
Gene Type	protein-coding
Description	cancer susceptibility candidate 3
Other Description	MLN 51\|barentsz\|cancer susceptibility candidate gene 3 protein\|metastatic lymph node 51\|metastatic lymph node gene 51 protein\|protein CASC3\|protein barentsz
Swissprots	A8K8R0 O15234
Accessions	EAW60643 EAW60644 O15234 AK096126 AK292425 BAF85114 AK296682 BAG59278 AK310635 BC030008 BC044656 AAH44656 BC050526 AAH50526 CA427444 DB082647 X80199 CAC27699 XM_005257163 XP_005257220 XR_934422 NM_007359 NP_031385
Function	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal ne
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress. {ECO:0000250}.
Tissue Specificity	Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers. {ECO:0000269\|PubMed:12080473}.
Top Pathways	RNA transport, mRNA surveillance pathway

CASC3 (G-10) - sc-376186 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CASC3 (G-10): sc-376186. Western blot analysis of CASC3 expression in non-transfected: sc-117752 (A) and human CASC3 transfected: sc-116218 (B) 293T whole cell lysates.

CASC3 (H-190) - sc-98359 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CASC3 (H-190): sc-98359. Western blot analysis of CASC3 expression in non-transfected: sc-117752 (A) and human CASC3 transfected: sc-116218 (B) 293T whole cell lysates.

Anti-MLN51/CASC3 antibody - ab135799 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MLN51/CASC3 antibody (ab135799) at 1/60 dilution + NCI-H460 cell line lysates at 35 µg

Anti-CASC3 / MLN51 Antibody (aa210-240, APC) - LS-C275907 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240, AP) - LS-C275908 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240, FITC) - LS-C275909 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240, Biotin) - LS-C275910 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240, Azide-free, HRP) - LS-C275912 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240, PE) - LS-C275913 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181, APC) - LS-C275915 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181, AP) - LS-C275914 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181, Biotin) - LS-C275916 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181, FITC) - LS-C275917 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181, PE) - LS-C275920 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (N-Terminus) - LS-C108019 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CASC3 antibody LS-C108019 Western blot of ACHN lysate.

Anti-CASC3 / MLN51 Antibody (Tyr181, Azide-free, HRP) - LS-C275919 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (Tyr181) - LS-C327016 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa210-240) - LS-C327014 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa653-703) - LS-C289208 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human CASC3 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-CASC3 used at a dilution of 1:200 (1 ug/ml).

Anti-CASC3 / MLN51 Antibody - LS-C334422 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using CASC3 antibody.

Anti-CASC3 / MLN51 Antibody (Tyr181) - LS-C100828 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CASC3 Antibody (Y181) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CASC3 / MLN51 Antibody (aa202-233) - LS-C100827 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CASC3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CASC3 / MLN51 Antibody (aa225-275) - LS-C289207 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC3 / MLN51 Antibody (aa653-703) - LS-C286895 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human CASC3 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CASC3 used at a dilution of 1:100. Detection:Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.

CASC3 Antibody - NBP1-88515 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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