CASC3

Gene Symbol	CASC3
Entrez Gene	22794
Alt Symbol	BTZ, MLN51
Species	Human
Gene Type	protein-coding
Description	cancer susceptibility candidate 3
Other Description	MLN 51|barentsz|cancer susceptibility candidate gene 3 protein|metastatic lymph node 51|metastatic lymph node gene 51 protein|protein CASC3|protein barentsz
Swissprots	A8K8R0 O15234
Accessions	EAW60643 EAW60644 O15234 AK096126 AK292425 BAF85114 AK296682 BAG59278 AK310635 BC030008 BC044656 AAH44656 BC050526 AAH50526 CA427444 DB082647 X80199 CAC27699 XM_005257163 XP_005257220 XR_934422 NM_007359 NP_031385
Function	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal ne
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress. {ECO:0000250}.
Tissue Specificity	Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers. {ECO:0000269|PubMed:12080473}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MLN51/CASC3 protein fragment - ab161425 from Abcam Category Protein Source Wheat germ Species Human

CASC3 / MLN51 Antibody Blocking Peptide - LS-E8817 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASC3 / MLN51 Antibody Blocking Peptide - LS-E19764 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CASC3 Protein - H00022794-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CASC3 Peptide - P2446 from Novus Biologicals Category Peptide Species Human

Phospho-CASC3Y181-Antibody-Blocking-peptide - BP3681a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

CASC3-Antibody-Y181-Blocking-Peptide - BP7264d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CASC3 Blocking Peptide - 33R-5626 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CASC3 - H00022794-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CASC3 - H00022794-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CASC3 fusion protein - ag12694 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Protein CASC3(CASC3) - CSB-YP004535HU CSB-EP004535HU CSB-BP004535HU CSB-MP004535HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CASC3 - TP308495 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CASC3 Protein - NBP1-88515PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

CASC3 Peptide, Human - M34GP02382H from Creative Peptides Category Peptide Source Synthetic. Species Human

CASC3 Recombinant Protein Antigen - NBP2-55636PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Protein CASC3 (CASC3), Recombinant Protein - MBS1220094 from MyBioSource Category Protein Prices $1,510.00, $1,510.00, $1,740.00, $1,740.00, $2,585.00, $2,585.00, $3,025.00, $3,025.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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