CASC3
| Gene Symbol | CASC3 |
|---|---|
| Entrez Gene | 22794 |
| Alt Symbol | BTZ, MLN51 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cancer susceptibility candidate 3 |
| Other Description | MLN 51|barentsz|cancer susceptibility candidate gene 3 protein|metastatic lymph node 51|metastatic lymph node gene 51 protein|protein CASC3|protein barentsz |
| Swissprots | A8K8R0 O15234 |
| Accessions | EAW60643 EAW60644 O15234 AK096126 AK292425 BAF85114 AK296682 BAG59278 AK310635 BC030008 BC044656 AAH44656 BC050526 AAH50526 CA427444 DB082647 X80199 CAC27699 XM_005257163 XP_005257220 XR_934422 NM_007359 NP_031385 |
| Function | Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal ne |
| Subcellular Location | Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers. {ECO:0000269|PubMed:12080473}. |
| Top Pathways | RNA transport, mRNA surveillance pathway |
CASC3 CRISPR/Cas9 KO Plasmid (h) - sc-411606 from Santa Cruz Biotechnology
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CASC3 HDR Plasmid (h) - sc-411606-HDR from Santa Cruz Biotechnology
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CASC3 Double Nickase Plasmid (h) - sc-411606-NIC from Santa Cruz Biotechnology
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CASC3 Double Nickase Plasmid (h2) - sc-411606-NIC-2 from Santa Cruz Biotechnology
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CASC3 CRISPR Activation Plasmid (h) - sc-411606-ACT from Santa Cruz Biotechnology
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CASC3 CRISPR Activation Plasmid (h2) - sc-411606-ACT-2 from Santa Cruz Biotechnology
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CASC3 Lentiviral Activation Particles (h) - sc-411606-LAC from Santa Cruz Biotechnology
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CASC3 Lentiviral Activation Particles (h2) - sc-411606-LAC-2 from Santa Cruz Biotechnology
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CASC3 siRNA (h) - sc-93943 from Santa Cruz Biotechnology
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CASC3 shRNA Plasmid (h) - sc-93943-SH from Santa Cruz Biotechnology
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CASC3 shRNA (h) Lentiviral Particles - sc-93943-V from Santa Cruz Biotechnology
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CASC3 RNAi - H00022794-R01 from Novus Biologicals
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MISSION® esiRNA - EHU058441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5377 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5377 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10225 from Sigma-Aldrich
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CASC3 siRNA (Human) - CRH7774 from Cohesion Biosciences
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CASC3 - MBS8239537 from MyBioSource
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shRNA set against Human CASC3 (NM_007359.4) - SHH254845 from Creative biogene
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shRNA set against Human CASC3(NM_007359.4) - SHG141811 from Creative biogene
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Human CASC3 siRNA - orb268276 from Biorbyt
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CASC3 shRNA Plasmid (Human) - CHH7774 from Cohesion Biosciences
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CASC3 miRNA 3'UTR clone - MiUTR3H-08521 from Creative biogene
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