| Gene Symbol |
CENPT
|
| Entrez Gene |
80152
|
| Alt Symbol |
C16orf56, CENP-T
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein T
|
| Other Description |
interphase centromere complex protein 22
|
| Swissprots |
Q96NK9 Q96I29 Q96IC6 Q9H901 Q96BT3
|
| Accessions |
EAW83178 EAW83179 Q96BT3 AK023173 BAB14445 AK055237 BAB70884 AK056097 BAG51624 AK125366 AK225399 AK291527 BAF84216 AK297570 BAG59961 AK300887 BAG62529 AK301621 BAG63106 BC007642 AAH07642 BC007864 AAH07864 BC015202 AAH15202 BC042204 BX648617 CD242240 XM_006721277 XP_006721340 XM_011523344 XP_011521646 XM_011523345 XP_011521647 NM_025082 NP_079358
|
| Function |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome- associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus.
|