| Gene Symbol |
TFAP2E
|
| Entrez Gene |
339488
|
| Alt Symbol |
AP2E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
|
| Other Description |
AP2-epsilon|activating enhancer-binding protein 2-epsilon|adaptor-related protein complex 2, epsilon subunit|transcription factor AP-2-epsilon
|
| Swissprots |
Q6VUC0 Q8IW12
|
| Accessions |
EAX07409 Q6VUC0 AY326454 AAQ91614 BC041175 AAH41175 BC150147 NM_178548 NP_848643
|
| Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q6VUP9}.
|
| Tissue Specificity |
Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line. {ECO:0000269|PubMed:14636996}.
|
