Gene Symbol | TFAP2E |
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Entrez Gene | 339488 |
Alt Symbol | AP2E |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) |
Other Description | AP2-epsilon|activating enhancer-binding protein 2-epsilon|adaptor-related protein complex 2, epsilon subunit|transcription factor AP-2-epsilon |
Swissprots | Q6VUC0 Q8IW12 |
Accessions | EAX07409 Q6VUC0 AY326454 AAQ91614 BC041175 AAH41175 BC150147 NM_178548 NP_848643 |
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:Q6VUP9}. |
Tissue Specificity | Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line. {ECO:0000269|PubMed:14636996}. |
AP-2ε CRISPR/Cas9 KO Plasmid (h) - sc-415518 from Santa Cruz Biotechnology
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AP-2ε HDR Plasmid (h) - sc-415518-HDR from Santa Cruz Biotechnology
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AP-2ε Double Nickase Plasmid (h) - sc-415518-NIC from Santa Cruz Biotechnology
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AP-2ε Double Nickase Plasmid (h2) - sc-415518-NIC-2 from Santa Cruz Biotechnology
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AP-2ε CRISPR Activation Plasmid (h) - sc-415518-ACT from Santa Cruz Biotechnology
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AP-2ε CRISPR Activation Plasmid (h2) - sc-415518-ACT-2 from Santa Cruz Biotechnology
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AP-2ε Lentiviral Activation Particles (h) - sc-415518-LAC from Santa Cruz Biotechnology
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AP-2ε Lentiviral Activation Particles (h2) - sc-415518-LAC-2 from Santa Cruz Biotechnology
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AP-2ε siRNA (h) - sc-88389 from Santa Cruz Biotechnology
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AP-2é shRNA Plasmid (h) - sc-88389-SH from Santa Cruz Biotechnology
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AP-2é shRNA (h) Lentiviral Particles - sc-88389-V from Santa Cruz Biotechnology
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AP-2 epsilon/TFAP2E RNAi - H00339488-R01 from Novus Biologicals
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MISSION® esiRNA - EHU154241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21248 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21248 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05440 from Sigma-Aldrich
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TFAP2E siRNA (Human) - CRJ7298 from Cohesion Biosciences
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TFAP2E - MBS8202125 from MyBioSource
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shRNA set against Human TFAP2E (NM_178548.3) - SHH426112 from Creative biogene
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Human TFAP2E siRNA - orb277799 from Biorbyt
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TFAP2E shRNA Plasmid (Human) - CHJ7298 from Cohesion Biosciences
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TFAP2E miRNA 3'UTR clone - MiUTR4H-TG08910 from Creative biogene
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