LRP8

Gene Symbol	LRP8
Entrez Gene	7804
Alt Symbol	APOER2, HSZ75190, LRP-8, MCI1
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Other Description	ApoE receptor 2|low-density lipoprotein receptor-related protein 8
Swissprots	B1AMT6 Q14114 Q99876 Q9BR78 B1AMT7 Q86V27 B1AMT8 O14968
Accessions	AAF66439 AAF66440 BAA21824 BAA21825 EAX06740 EAX06741 EAX06742 EAX06743 EAX06744 EAX06745 Q14114 AA775280 AK096482 BAG53302 AK122887 AL119002 BC006443 AAH06443 BC051836 AAH51836 BE543079 BM477111 CD300289 CF593917 D50678 BAA09328 DB452432 DB455425 DR002432 HG492034 Z75190 CAA99509 XM_005271173 XP_005271230 XM_005271174 XP_005271231 XM_005271175 XP_005271232 XM_006710881 XP_006710944 XM_006710882 XP_006710945 XM_011542094 XP_011540396 XM_011542095 XP_011540397 XM_011542096 XP_011540398 XM_011542097 XP_011540399 NM_001018054 NP_001018064 NM_004631 NP_004622 NM_017522 NP_059992 NM_033300 NP_150643
Function	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an en
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}.
Tissue Specificity	Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat APOER2 / LRP8 ELISA Kit (Sandwich ELISA) - LS-F8500 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 13.3 pg/ml Range 31.25-2000 pg/ml

Low-density lipoprotein receptor-related protein 8, LRP8, Human, ELISA Kit - E10006h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.312-20 ng/mL

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS079126 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS092950 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS094236 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS091423 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 ng/ml. Range 31.2 ng/ml - 1000 ng/ml.

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS091953 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS075587 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS088398 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS104019 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS065118 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS101505 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS100754 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS072852 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS092080 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS075185 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS102838 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS078784 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS074689 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS063937 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS106952 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS073208 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8, ELISA Kit - MBS055289 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Low Density Lipoprotein Receptor Related Protein 8 (LRP8), ELISA Kit - MBS2021336 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 13.3pg/mL. Range 31.25-2000pg/mL

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, ELISA Kit - MBS9339986 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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