LRP8

Gene Symbol	LRP8
Entrez Gene	7804
Alt Symbol	APOER2, HSZ75190, LRP-8, MCI1
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Other Description	ApoE receptor 2|low-density lipoprotein receptor-related protein 8
Swissprots	B1AMT6 Q14114 Q99876 Q9BR78 B1AMT7 Q86V27 B1AMT8 O14968
Accessions	AAF66439 AAF66440 BAA21824 BAA21825 EAX06740 EAX06741 EAX06742 EAX06743 EAX06744 EAX06745 Q14114 AA775280 AK096482 BAG53302 AK122887 AL119002 BC006443 AAH06443 BC051836 AAH51836 BE543079 BM477111 CD300289 CF593917 D50678 BAA09328 DB452432 DB455425 DR002432 HG492034 Z75190 CAA99509 XM_005271173 XP_005271230 XM_005271174 XP_005271231 XM_005271175 XP_005271232 XM_006710881 XP_006710944 XM_006710882 XP_006710945 XM_011542094 XP_011540396 XM_011542095 XP_011540397 XM_011542096 XP_011540398 XM_011542097 XP_011540399 NM_001018054 NP_001018064 NM_004631 NP_004622 NM_017522 NP_059992 NM_033300 NP_150643
Function	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an en
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}.
Tissue Specificity	Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ApoER2 peptide - ab193569 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human ApoER2 protein fragment - ab152817 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

APOER2 / LRP8 Antibody Blocking Peptide - LS-E16275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APOER2 / LRP8 Antibody Blocking Peptide - LS-E8100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APOER2 / LRP8 Antibody Blocking Peptide - LS-E16432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Apolipoprotein E R2/ApoE R2 Protein - H00007804-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Apolipoprotein E R2/ApoE R2 Peptide - P1767 from Novus Biologicals Category Peptide Species Human

APOER2-LRP8-Antibody-C-term-Blocking-peptide - BP6159a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Apolipoprotein E R2, CF - 3520-AR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Asp35-Lys818 (Ala262Val), with a C-terminal 10-His tag

Lrp8 Blocking Peptide - 33R-1206 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LRP8 Blocking Peptide - 33R-1575 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human LRP8 Protein - abx067824 from Abbexa Category Protein Source E.coli Species Human

APOER2 / LRP8 - H00007804-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

APOER2 / LRP8 - H00007804-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Low Density Lipoprotein Receptor Related Protein - 20-8676 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

LRP8 fusion protein - ag20394 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LRP8 fusion protein - ag12698 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ApoE R2, CF - LRP8-64H from Creative Biomart Category Protein Source CHO cells Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) - RPD099Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) - RPD099Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Apolipoprotein E Receptor 2 Blocking Peptide - CBP2717 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ApoER2 Peptide - BS5615P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) - RPD099Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Low-density lipoprotein receptor-related protein 8(LRP8) - CSB-YP623900HU CSB-EP623900HU CSB-BP623900HU CSB-MP623900HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Apolipoprotein E R2 Protein, CF - 3520-AR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Asp35-Lys818 (Ala262Val), with a C-terminal 10-His tag Species Human

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