| Gene Symbol |
LRP8
|
| Entrez Gene |
7804
|
| Alt Symbol |
APOER2, HSZ75190, LRP-8, MCI1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
|
| Other Description |
ApoE receptor 2|low-density lipoprotein receptor-related protein 8
|
| Swissprots |
B1AMT6 Q14114 Q99876 Q9BR78 B1AMT7 Q86V27 B1AMT8 O14968
|
| Accessions |
AAF66439 AAF66440 BAA21824 BAA21825 EAX06740 EAX06741 EAX06742 EAX06743 EAX06744 EAX06745 Q14114 AA775280 AK096482 BAG53302 AK122887 AL119002 BC006443 AAH06443 BC051836 AAH51836 BE543079 BM477111 CD300289 CF593917 D50678 BAA09328 DB452432 DB455425 DR002432 HG492034 Z75190 CAA99509 XM_005271173 XP_005271230 XM_005271174 XP_005271231 XM_005271175 XP_005271232 XM_006710881 XP_006710944 XM_006710882 XP_006710945 XM_011542094 XP_011540396 XM_011542095 XP_011540397 XM_011542096 XP_011540398 XM_011542097 XP_011540399 NM_001018054 NP_001018064 NM_004631 NP_004622 NM_017522 NP_059992 NM_033300 NP_150643
|
| Function |
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an en
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}.
|
| Tissue Specificity |
Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}.
|
![Western Blot: ApoER2 Overexpression Lysate (Native) [NBP2-06973] - ApoER2 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LRP8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8356_ApoER2-Overexpression-Lysate-(Native)-Western-Blot-NBP2-06973-img0003.jpg)