PLA2G3

Gene Symbol PLA2G3
Entrez Gene 50487
Alt Symbol GIII-SPLA2, SPLA2III, sPLA2-III
Species Human
Gene Type protein-coding
Description phospholipase A2, group III
Other Description group 3 secretory phospholipase A2|group III secreted phospholipase A2|phosphatidylcholine 2-acylhydrolase 3|phosphatidylcholine 2-acylhydrolase GIII
Swissprots O95768 Q9NZ20
Accessions AAD15617 EAW59941 Q9NZ20 AF220490 AAF44746 BC025316 AAH25316 DQ892832 ABM83758 DQ896078 ABM87077 XM_011530203 XP_011528505 XM_011530204 XP_011528506 XM_011530205 XP_011528507 XR_937865 NM_015715 NP_056530
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:20393563}.
Subcellular Location Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level). {ECO:0000269|PubMed:15863501}.
Top Pathways Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism

group III sPLA 2 (K-16) - sc-86473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLA2G3 antibody - ab96533 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PLA2G3 antibody (ab96533) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-PLA2G3 antibody - ab133830 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PLA2G3 antibody (ab133830) at 1 µg/ml + HT1080 cell lysate at 10 µg

Anti-PLA2G3 antibody - ab169078 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PLA2G3 antibody (ab169078) at 1 µg/mlLane 1 : PLA2G3-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-PLA2G3 antibody - ab62197 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded colonic carcinoma tissue, using ab62197 at 2.5µg/ml.

Anti-PLA2G3 Antibody (Internal) IHC-plus™ - LS-A9485 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PLA2G3 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PLA2G3 Antibody (Internal) IHC-plus™ - LS-A9486 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PLA2G3 antibody LS-A9486 IHC of human colon carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PLA2G3 Antibody (aa446-474, APC) - LS-C239125 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa446-474, AP) - LS-C239126 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa446-474, FITC) - LS-C239127 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa446-474, Biotin) - LS-C239128 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa446-474, PE) - LS-C239132 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa446-474, Azide-free, HRP) - LS-C248491 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (C-Terminus) - LS-C151990 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PLA2G3 antibody Western Blot of HT1080.

Anti-PLA2G3 Antibody (aa445-474) - LS-C324084 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2G3 Antibody (aa263-502) - LS-C186177 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. PLA2G3 antibody diluted at 1:1000.

Anti-PLA2G3 Antibody (aa446-474) - LS-C158671 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PLA2G3 Antibody western blot of Uterus tissue lysates (35 ug/lane). The PLA2G3 antibody detected the PLA2G3 protein (arrow).

PLA2G3 Antibody - NBP1-83367 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLA2G3 Antibody [NBP1-83367] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

PLA2G3 Antibody - NBP1-33322 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLA2G3 Antibody [NBP1-33322] - Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE; antibody diluted at 1:1000.

PLA2G3 Antibody - NB100-59030 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PLA2G3 Antibody [NB100-59030] - Analysis of anti-PLA2G3 antibody with human colon, carcinoma at concentration 10 ug/ml.

PLA2G3 Antibody - NB100-59031 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PLA2G3 Antibody - H00050487-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

PLA2G3 Antibody - H00050487-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PLA2G3 Antibody [H00050487-D01P] - Analysis of PLA2G3 expression in mouse liver.

PLA2G3 Antibody - H00050487-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLA2G3 Antibody - H00050487-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PLA2G3 Antibody [H00050487-B01P] - Analysis of PLA2G3 expression in transfected 293T cell line by PLA2G3 polyclonal antibody. Lane 1: PLA2G3 transfected lysate(55.99 KDa). Lane 2: Non-transfected lysate.
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