PLA2G3

Gene Symbol	PLA2G3
Entrez Gene	50487
Alt Symbol	GIII-SPLA2, SPLA2III, sPLA2-III
Species	Human
Gene Type	protein-coding
Description	phospholipase A2, group III
Other Description	group 3 secretory phospholipase A2|group III secreted phospholipase A2|phosphatidylcholine 2-acylhydrolase 3|phosphatidylcholine 2-acylhydrolase GIII
Swissprots	O95768 Q9NZ20
Accessions	AAD15617 EAW59941 Q9NZ20 AF220490 AAF44746 BC025316 AAH25316 DQ892832 ABM83758 DQ896078 ABM87077 XM_011530203 XP_011528505 XM_011530204 XP_011528506 XM_011530205 XP_011528507 XR_937865 NM_015715 NP_056530
Function	PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:20393563}.
Subcellular Location	Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity	Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level). {ECO:0000269|PubMed:15863501}.
Top Pathways	Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PLA2G3 protein fragment - ab162339 from Abcam Category Protein Source Wheat germ Species Human

PLA2G3 Antibody Blocking Peptide - LS-E6212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLA2G3 Antibody Blocking Peptide - LS-E23837 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLA2G3 Antibody Blocking Peptide - LS-E29666 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PLA2G3 Antibody Blocking Peptide - LS-E29665 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PLA2G3 Protein - H00050487-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLA2G3-Antibody-C-term-Blocking-Peptide - BP18856b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLA2G3 / sPLA2-III - H00050487-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLA2G3 / sPLA2-III - H00050487-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLA2G3 fusion protein - ag11845 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Phospholipase A2, Group III (PLA2G3) - RPD831Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Phospholipase A2, Group III (PLA2G3) - RPD831Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Group 3 secretory phospholipase A2(PLA2G3) - CSB-YP882150HU CSB-EP882150HU CSB-BP882150HU CSB-MP882150HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PLA2G3 Recombinant Protein Antigen - NBP1-83367PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLA2G3 Peptide, Human - M34GP11870H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Phospholipase A2, Group III (PLA2G3) - RPU53631 from Biomatik Category Protein Prices $198.00, $387.00, $619.00, $738.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

PLA2G3 Recombinant Protein (OPCD00181) - OPCD00181 from Aviva Systems Biology Category Protein Source E.coli Species Human

Group 3 secretory phospholipase A2 (PLA2G3), Recombinant Protein - MBS1378612 from MyBioSource Category Protein Prices $1,275.00, $1,275.00, $1,495.00, $1,495.00, $2,090.00, $2,090.00, $2,555.00, $2,555.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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