PLA2G3

Gene Symbol PLA2G3
Entrez Gene 50487
Alt Symbol GIII-SPLA2, SPLA2III, sPLA2-III
Species Human
Gene Type protein-coding
Description phospholipase A2, group III
Other Description group 3 secretory phospholipase A2|group III secreted phospholipase A2|phosphatidylcholine 2-acylhydrolase 3|phosphatidylcholine 2-acylhydrolase GIII
Swissprots O95768 Q9NZ20
Accessions AAD15617 EAW59941 Q9NZ20 AF220490 AAF44746 BC025316 AAH25316 DQ892832 ABM83758 DQ896078 ABM87077 XM_011530203 XP_011528505 XM_011530204 XP_011528506 XM_011530205 XP_011528507 XR_937865 NM_015715 NP_056530
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:20393563}.
Subcellular Location Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level). {ECO:0000269|PubMed:15863501}.
Top Pathways Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism

Mouse PLA2G3 ELISA Kit (Sandwich ELISA) - LS-F9344 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.27 ng/ml
Range 0.781-50 ng/ml

PLA2G3 (Human) IP-WB Antibody Pair - H00050487-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

phospholipase A2, group III, ELISA Kit - MBS9333034 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS105536 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS066147 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS105341 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS059005 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS064918 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS088254 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III, ELISA Kit - MBS063185 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase A2, Group III (PLA2G3), ELISA Kit - MBS2019805 from MyBioSource

Category ELISA Kit
Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.27ng/mL.
Range 0.781-50ng/mL

ELISA Kit for Phospholipase A2, Group III (PLA2G3) - SED831Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.27ng/mL.
Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human PLA2G3 ELISA Kit - E029171 from Biobool

Category ELISA Kit

Phospholipase A2, Group III (PLA2G3), ELISA Kit - MBS9379483 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Group 3 Secretory Phospholipase A2 (PLA2G3), ELISA Kit - MBS9909087 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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