| Gene Symbol |
KRT71
|
| Entrez Gene |
112802
|
| Alt Symbol |
HYPT13, K6IRS1, KRT6IRS, KRT6IRS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 71, type II
|
| Other Description |
CK-71|K71|cytokeratin-71|hK6irs|hK6irs1|keratin 6 irs|keratin, type II cytoskeletal 71|keratin-71|type II inner root sheath-specific keratin-K6irs1|type-II keratin Kb34
|
| Swissprots |
Q96DU2 Q3SY84 B3KVC1 Q3SY85
|
| Accessions |
EAW96636 Q3SY84 AJ308599 CAC43429 AJ308600 AJ308601 AK122795 BAG53733 BC103917 AAI03918 BC103918 AAI03919 EU832765 ACE87776 GQ129308 ACT64442 NM_033448 NP_258259
|
| Function |
Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269|PubMed:22592156}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22592156}.
|
| Tissue Specificity |
Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:11982755, ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:22592156}.
|