Gene Symbol | KRT71 |
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Entrez Gene | 112802 |
Alt Symbol | HYPT13, K6IRS1, KRT6IRS, KRT6IRS1 |
Species | Human |
Gene Type | protein-coding |
Description | keratin 71, type II |
Other Description | CK-71|K71|cytokeratin-71|hK6irs|hK6irs1|keratin 6 irs|keratin, type II cytoskeletal 71|keratin-71|type II inner root sheath-specific keratin-K6irs1|type-II keratin Kb34 |
Swissprots | Q96DU2 Q3SY84 B3KVC1 Q3SY85 |
Accessions | EAW96636 Q3SY84 AJ308599 CAC43429 AJ308600 AJ308601 AK122795 BAG53733 BC103917 AAI03918 BC103918 AAI03919 EU832765 ACE87776 GQ129308 ACT64442 NM_033448 NP_258259 |
Function | Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269|PubMed:22592156}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22592156}. |
Tissue Specificity | Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:11982755, ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:22592156}. |
Keratin 71 CRISPR/Cas9 KO Plasmid (h) - sc-414007 from Santa Cruz Biotechnology
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Keratin 71 HDR Plasmid (h) - sc-414007-HDR from Santa Cruz Biotechnology
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Keratin 71 Double Nickase Plasmid (h) - sc-414007-NIC from Santa Cruz Biotechnology
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Keratin 71 Double Nickase Plasmid (h2) - sc-414007-NIC-2 from Santa Cruz Biotechnology
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Keratin 71 CRISPR Activation Plasmid (h) - sc-414007-ACT from Santa Cruz Biotechnology
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Keratin 71 CRISPR Activation Plasmid (h2) - sc-414007-ACT-2 from Santa Cruz Biotechnology
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Keratin 71 Lentiviral Activation Particles (h) - sc-414007-LAC from Santa Cruz Biotechnology
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Keratin 71 Lentiviral Activation Particles (h2) - sc-414007-LAC-2 from Santa Cruz Biotechnology
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Keratin 71 siRNA (h) - sc-96042 from Santa Cruz Biotechnology
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Keratin 71 shRNA Plasmid (h) - sc-96042-SH from Santa Cruz Biotechnology
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Keratin 71 shRNA (h) Lentiviral Particles - sc-96042-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11396 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11396 from Sigma-Aldrich
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KRT71 siRNA (Human) - CRJ4291 from Cohesion Biosciences
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shRNA set against Human KRT71 (NM_033448.2) - SHH327627 from Creative biogene
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KRT71 shRNA Plasmid (Human) - CHJ4291 from Cohesion Biosciences
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KRT71 miRNA 3'UTR clone - MiUTR3H-09867 from Creative biogene
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