CDC42BPA

Gene Symbol CDC42BPA
Entrez Gene 8476
Alt Symbol MRCK, MRCKA, PK428
Species Human
Gene Type protein-coding
Description CDC42 binding protein kinase alpha (DMPK-like)
Other Description CDC42 binidng protein kinase beta|CDC42-binding protein kinase alpha (DMPK-like)|DMPK-like alpha|MRCK alpha|myotonic dystrophy kinase-related CDC42-binding kinase alpha|myotonic dystrophy kinase-related CDC42-binding protein kinase alpha|myotonic dystrophy protein kinase-like alpha|ser-thr protein kinase PK428|ser-thr protein kinase related to the myotonic dystrophy protein kinase|serine/threonine-protein kinase MRCK alpha
Swissprots Q86XX2 Q5VT26 Q99646 Q5H9N9 O75039 Q5T797 Q5VT27 Q59GZ1 Q5VT25 Q86XX3
Accessions EAW69806 EAW69807 EAW69808 EAW69809 Q5VT25 AB007920 BAA32296 AB208968 BAD92205 AF250871 AAF66437 AJ518975 CAD57745 AJ518976 CAD57746 AK027000 BAB15619 AK130237 AY166586 AAN86031 BC008677 BC038993 BC050335 BC127831 BC136333 AAI36334 BC156892 AAI56893 BF765241 BQ232716 BX648219 BX648693 CAI45998 CR933723 CAI46252 U59305 AAB37126 XM_005273317 XP_005273374 XM_005273318 XP_005273375 XM_005273320 XP_005273377 XM_005273321 XP_005273378 XM_005273322 XP_005273379 XM_005273324 XP_005273381 XM_006711834 XP_006711897 XM_006711835 XP_006711898 XM_011544306 XP_011542608 XM_011544307 XP_011542609 XM_011544308 XP_011542610 XM_011544309 XP_011542611 NM_003607 NP_003598 NM_014826 NP_055641
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.
Tissue Specificity Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}.

MRCKα (B-3) - sc-374568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRCKα (B-3): sc-374568. Western blot analysis of MRCKα expression in rat brain tissue extract.

MRCKα (E-20) - sc-15295 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MRCKα (H-90) - sc-48833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MRCKα (H-90): sc-48833. Western blot analysis of MRCKα expression in COLO 320DM whole cell lysate (A) and mouse brain tissue extract (B).

Anti-CDC42 binding protein kinase alpha antibody - ab96659 from Abcam

Prices $304.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CDC42 binding protein kinase alpha antibody (ab96659) at 1/1500 dilution + H1299 whole cell lysate at 30 µg

Anti-CDC42 binding protein kinase alpha antibody - ab196813 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC42 binding protein kinase alpha antibody - ab113710 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab113710 at 3.75 µg/ml staining CDC42 binding protein kinase alpha in Formalin-Fixed, Paraffin-Embedded Human brain cerebellum tissue.

Anti-CDC42 binding protein kinase alpha antibody - ab56479 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-CDC42 binding protein kinase alpha antibody - N-terminal (ab187310) at 1/1000 dilution + Mouse thymus total cell extracts

Anti-CDC42BPA / MRCK Antibody (aa373-564) - LS-C185496 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SW480 xenograft using MRCK alpha antibody at 1:100 dilution.

Anti-CDC42BPA / MRCK Antibody (N-Terminus) IHC-plus™ - LS-B4970 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CDC42BPA / MRCK antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4970 concentration 3.75 ug/ml.

Anti-CDC42BPA / MRCK Antibody (aa551-650, clone 10B2176, Azide-free) - LS-C183509 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10B2176

Anti-CDC42BPA / MRCK Antibody (Leu663) - LS-C193192 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC42BPA / MRCK Antibody (aa1671-1685) - LS-C204301 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC42BPA / MRCK Antibody (aa1610-1660) - LS-C289415 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC42BPA / MRCK Antibody (aa1560-1610) - LS-C289414 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC42BPA / MRCK Antibody (clone 1G7) - LS-C198572 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G7
Detection limit for recombinant GST tagged CDC42BPA is approximately 0.03 ng/ml as a capture antibody.

MRCK Antibody (1G7) - H00008476-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G7
Western Blot: MRCK Antibody (1G7) [H00008476-M01] - Western Blot analysis of CDC42BPA expression in A-549 ( Cat # L025V1 ).

MRCK Antibody - NB300-829 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

MRCK Antibody - NBP1-46823 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: MRCK Antibody [NBP1-46823] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.  Antibodies: Affinity purified rabbit anti-MRCK antibody NBP1-46823 used for IP at 3 ug/mg lysate.  MRCK was also immunoprecipitated by rabbit anti-MRCK antibody NBP1-46822, which recognizes an upstream epitope.  For blotting immunoprecipitated MRC, NBP1-46822 was used at 1 ug/ml.  Detection: Chemiluminescence with an exposure time of 10 seconds.

MRCK Antibody - NBP1-46822 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: MRCK Antibody [NBP1-46822] - Samples:  Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells.  Antibodies: Affinity purified rabbit anti-MRCK antibody NBP1-46822 used for IP at 3 ug/mg lysate.  MRCK was also immunoprecipitated by rabbit anti-MRCK antibody NBP1-46823, which recognizes a downstream epitope.  For blotting immunoprecipitated MRCK, NBP1-46822 was used at 1 ug/ml.  Detection: Chemiluminescence with an exposure time of 10 seconds.

Monoclonal Anti-CDC42BPA antibody produced in mouse - WH0008476M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G7
<B>Immunoblotting</B><BR/>Monoclonal Anti-CDC42BPA, <B>Cat. No. WH0008476M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~117.7 kDa using A-549 lysate.

Anti-CDC42BPA (N-terminal) antibody produced in goat - SAB2501797 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

CDC42BPA-Antibody-monoclonal-M01 - AT1463a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .

Cdc42-binding-kinase-alpha-Antibody-N-Term - AF2407a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2407a (3.8 µg/ml) staining of paraffin embedded Human Cerebellum Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

MRCK alpha antibody, N-term - GTX89739 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-Cdc42-binding kinase alpha antibody, N-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX89739
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