Gene Symbol | CDC42BPA |
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Entrez Gene | 8476 |
Alt Symbol | MRCK, MRCKA, PK428 |
Species | Human |
Gene Type | protein-coding |
Description | CDC42 binding protein kinase alpha (DMPK-like) |
Other Description | CDC42 binidng protein kinase beta|CDC42-binding protein kinase alpha (DMPK-like)|DMPK-like alpha|MRCK alpha|myotonic dystrophy kinase-related CDC42-binding kinase alpha|myotonic dystrophy kinase-related CDC42-binding protein kinase alpha|myotonic dystrophy protein kinase-like alpha|ser-thr protein kinase PK428|ser-thr protein kinase related to the myotonic dystrophy protein kinase|serine/threonine-protein kinase MRCK alpha |
Swissprots | Q86XX2 Q5VT26 Q99646 Q5H9N9 O75039 Q5T797 Q5VT27 Q59GZ1 Q5VT25 Q86XX3 |
Accessions | EAW69806 EAW69807 EAW69808 EAW69809 Q5VT25 AB007920 BAA32296 AB208968 BAD92205 AF250871 AAF66437 AJ518975 CAD57745 AJ518976 CAD57746 AK027000 BAB15619 AK130237 AY166586 AAN86031 BC008677 BC038993 BC050335 BC127831 BC136333 AAI36334 BC156892 AAI56893 BF765241 BQ232716 BX648219 BX648693 CAI45998 CR933723 CAI46252 U59305 AAB37126 XM_005273317 XP_005273374 XM_005273318 XP_005273375 XM_005273320 XP_005273377 XM_005273321 XP_005273378 XM_005273322 XP_005273379 XM_005273324 XP_005273381 XM_006711834 XP_006711897 XM_006711835 XP_006711898 XM_011544306 XP_011542608 XM_011544307 XP_011542609 XM_011544308 XP_011542610 XM_011544309 XP_011542611 NM_003607 NP_003598 NM_014826 NP_055641 |
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}. |
Tissue Specificity | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}. |
MRCKα (B-3) - sc-374568 from Santa Cruz Biotechnology
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MRCKα (E-20) - sc-15295 from Santa Cruz Biotechnology
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MRCKα (H-90) - sc-48833 from Santa Cruz Biotechnology
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Anti-CDC42 binding protein kinase alpha antibody - ab96659 from Abcam
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Anti-CDC42 binding protein kinase alpha antibody - ab196813 from Abcam
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Anti-CDC42 binding protein kinase alpha antibody - ab113710 from Abcam
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Anti-CDC42 binding protein kinase alpha antibody - ab56479 from Abcam
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Anti-CDC42 binding protein kinase alpha antibody - N-terminal - ab187310 from Abcam
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Anti-CDC42BPA / MRCK Antibody (aa373-564) - LS-C185496 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (N-Terminus) IHC-plus™ - LS-B4970 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (aa551-650, clone 10B2176, Azide-free) - LS-C183509 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (Leu663) - LS-C193192 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (aa1671-1685) - LS-C204301 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (aa1610-1660) - LS-C289415 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (aa1560-1610) - LS-C289414 from LifeSpan Bioscience
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Anti-CDC42BPA / MRCK Antibody (clone 1G7) - LS-C198572 from LifeSpan Bioscience
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MRCK Antibody (1G7) - H00008476-M01 from Novus Biologicals
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MRCK Antibody - NB300-829 from Novus Biologicals
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MRCK Antibody - NBP1-46823 from Novus Biologicals
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MRCK Antibody - NBP1-46822 from Novus Biologicals
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Monoclonal Anti-CDC42BPA antibody produced in mouse - WH0008476M1 from Sigma-Aldrich
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Anti-CDC42BPA (N-terminal) antibody produced in goat - SAB2501797 from Sigma-Aldrich
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CDC42BPA-Antibody-monoclonal-M01 - AT1463a from Abgent, a WuXi AppTec company
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Cdc42-binding-kinase-alpha-Antibody-N-Term - AF2407a from Abgent, a WuXi AppTec company
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MRCK alpha antibody, N-term - GTX89739 from GeneTex
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