CDC42BPA

Gene Symbol	CDC42BPA
Entrez Gene	8476
Alt Symbol	MRCK, MRCKA, PK428
Species	Human
Gene Type	protein-coding
Description	CDC42 binding protein kinase alpha (DMPK-like)
Other Description	CDC42 binidng protein kinase beta|CDC42-binding protein kinase alpha (DMPK-like)|DMPK-like alpha|MRCK alpha|myotonic dystrophy kinase-related CDC42-binding kinase alpha|myotonic dystrophy kinase-related CDC42-binding protein kinase alpha|myotonic dystrophy protein kinase-like alpha|ser-thr protein kinase PK428|ser-thr protein kinase related to the myotonic dystrophy protein kinase|serine/threonine-protein kinase MRCK alpha
Swissprots	Q86XX2 Q5VT26 Q99646 Q5H9N9 O75039 Q5T797 Q5VT27 Q59GZ1 Q5VT25 Q86XX3
Accessions	EAW69806 EAW69807 EAW69808 EAW69809 Q5VT25 AB007920 BAA32296 AB208968 BAD92205 AF250871 AAF66437 AJ518975 CAD57745 AJ518976 CAD57746 AK027000 BAB15619 AK130237 AY166586 AAN86031 BC008677 BC038993 BC050335 BC127831 BC136333 AAI36334 BC156892 AAI56893 BF765241 BQ232716 BX648219 BX648693 CAI45998 CR933723 CAI46252 U59305 AAB37126 XM_005273317 XP_005273374 XM_005273318 XP_005273375 XM_005273320 XP_005273377 XM_005273321 XP_005273378 XM_005273322 XP_005273379 XM_005273324 XP_005273381 XM_006711834 XP_006711897 XM_006711835 XP_006711898 XM_011544306 XP_011542608 XM_011544307 XP_011542609 XM_011544308 XP_011542610 XM_011544309 XP_011542611 NM_003607 NP_003598 NM_014826 NP_055641
Function	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.
Tissue Specificity	Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDC42 binding protein kinase alpha protein fragment - ab59979 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human CDC42 binding protein kinase alpha protein fragment - ab160046 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDC42BPA / MRCK Antibody Blocking Peptide - LS-E25721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MRCK Protein - H00008476-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MRCK beta (Active) recombinant protein - GTX65307 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

MRCK alpha blocking peptide - GTX89739-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

CDC42BPA peptide - orb218145 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MRCK beta protein - 30R-2882 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

MRCK alpha Blocking Peptide - abx063476 from Abbexa Category Peptide Species Human, Mouse, Rat

MRCK alpha Blocking Peptide - abx161169 from Abbexa Category Peptide Species Human, Mouse, Rat

CDC42 Binding Protein Kinase alpha Peptide - AC21-0550-P from Abcore Category Protein Prices $160.00 Sizes 100 µg

CDC42BPA - H00008476-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDC42BPA - H00008476-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDC42BPA - P5603 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Cdc42-binding kinase alpha Peptide - 45-384P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human CDC42 Binding Protein Kinase Alpha (DMPK-like), His-tagged - CDC42BPA-368H from Creative Biomart Category Protein Source Insectcells Species Human

Recombinant Human CDC42BPA, GST-tagged, Active - CDC42BPA-357H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human CDC42BPA - CDC42BPA-26225TH from Creative Biomart Category Protein

MRCK alpha Blocking Peptide - CBP2282 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MRCK alpha Blocking Peptide - CBP3668 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

MRCKα (L663) Peptide - BS9192P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Serine/threonine-protein kinase MRCK alpha(CDC42BPA) ,partial - CSB-YP736195HU CSB-EP736195HU CSB-BP736195HU CSB-MP736195HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cdc42-binding kinase alpha, Peptide - MBS426974 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Recombinant Human CDC42BPA (aa 1-473) His - CSI13391 from Cell Science Prices $615.00 Sizes 10 μg Species Human

MRCKα Protein, active, 250 µg - 14-691M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-691) and in bulk (cat# 14-691-K) Source MRCKα, amino acids 1-473, expressed by baculovirus in Sf21 cells

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