CDC42BPA

Gene Symbol CDC42BPA
Entrez Gene 8476
Alt Symbol MRCK, MRCKA, PK428
Species Human
Gene Type protein-coding
Description CDC42 binding protein kinase alpha (DMPK-like)
Other Description CDC42 binidng protein kinase beta|CDC42-binding protein kinase alpha (DMPK-like)|DMPK-like alpha|MRCK alpha|myotonic dystrophy kinase-related CDC42-binding kinase alpha|myotonic dystrophy kinase-related CDC42-binding protein kinase alpha|myotonic dystrophy protein kinase-like alpha|ser-thr protein kinase PK428|ser-thr protein kinase related to the myotonic dystrophy protein kinase|serine/threonine-protein kinase MRCK alpha
Swissprots Q86XX2 Q5VT26 Q99646 Q5H9N9 O75039 Q5T797 Q5VT27 Q59GZ1 Q5VT25 Q86XX3
Accessions EAW69806 EAW69807 EAW69808 EAW69809 Q5VT25 AB007920 BAA32296 AB208968 BAD92205 AF250871 AAF66437 AJ518975 CAD57745 AJ518976 CAD57746 AK027000 BAB15619 AK130237 AY166586 AAN86031 BC008677 BC038993 BC050335 BC127831 BC136333 AAI36334 BC156892 AAI56893 BF765241 BQ232716 BX648219 BX648693 CAI45998 CR933723 CAI46252 U59305 AAB37126 XM_005273317 XP_005273374 XM_005273318 XP_005273375 XM_005273320 XP_005273377 XM_005273321 XP_005273378 XM_005273322 XP_005273379 XM_005273324 XP_005273381 XM_006711834 XP_006711897 XM_006711835 XP_006711898 XM_011544306 XP_011542608 XM_011544307 XP_011542609 XM_011544308 XP_011542610 XM_011544309 XP_011542611 NM_003607 NP_003598 NM_014826 NP_055641
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Subcellular Location Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.
Tissue Specificity Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}.

MRCKα CRISPR/Cas9 KO Plasmid (h) - sc-403627 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα HDR Plasmid (h) - sc-403627-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα Double Nickase Plasmid (h) - sc-403627-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα Double Nickase Plasmid (h2) - sc-403627-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα CRISPR Activation Plasmid (h) - sc-403627-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα CRISPR Activation Plasmid (h2) - sc-403627-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα Lentiviral Activation Particles (h) - sc-403627-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα Lentiviral Activation Particles (h2) - sc-403627-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRCKα siRNA (h) - sc-60058 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRCKα shRNA Plasmid (h) - sc-60058-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRCKα shRNA (h) Lentiviral Particles - sc-60058-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRCK RNAi - H00008476-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MRCK RNAi - H00008476-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU158751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0324 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0325 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0323 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN5783 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5783 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

CDC42BPA siRNA (Human) - CRH5556 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CDC42BPA - MBS8209767 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CDC42BPA (NM_003607.3) - SHH259821 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CDC42BPA(NM_014826.4) - SHG161533 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CDC42BPA(NM_003607.3) - SHG161551 from Creative biogene

Category siRNA
Species Reactivities Human

Human CDC42BPA siRNA - orb266058 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
Search more