| Gene Symbol | CISH |
|---|---|
| Entrez Gene | 1154 |
| Alt Symbol | BACTS2, CIS, CIS-1, G18, SOCS |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytokine inducible SH2-containing protein |
| Other Description | cytokine-inducible SH2-containing protein|cytokine-inducible inhibitor of signaling type 1B|suppressor of cytokine signaling |
| Swissprots | Q9NS38 Q9Y5R1 G5E9R1 B2R9N1 Q9NSE2 |
| Accessions | AAQ13420 EAW65127 EAW65128 EAW65129 EAW65130 Q9NSE2 AF035947 AAF97410 AF132297 AAD28471 AK313850 BAG36578 BC031590 AAH31590 BC064354 AAH64354 BF511692 CA435538 D83532 BAA92328 DA957793 XM_011533329 XP_011531631 NM_013324 NP_037456 NM_145071 NP_659508 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}. |
| Top Pathways | Jak-STAT signaling pathway, Prolactin signaling pathway |