CISH

Gene Symbol	CISH
Entrez Gene	1154
Alt Symbol	BACTS2, CIS, CIS-1, G18, SOCS
Species	Human
Gene Type	protein-coding
Description	cytokine inducible SH2-containing protein
Other Description	cytokine-inducible SH2-containing protein|cytokine-inducible inhibitor of signaling type 1B|suppressor of cytokine signaling
Swissprots	Q9NS38 Q9Y5R1 G5E9R1 B2R9N1 Q9NSE2
Accessions	AAQ13420 EAW65127 EAW65128 EAW65129 EAW65130 Q9NSE2 AF035947 AAF97410 AF132297 AAD28471 AK313850 BAG36578 BC031590 AAH31590 BC064354 AAH64354 BF511692 CA435538 D83532 BAA92328 DA957793 XM_011533329 XP_011531631 NM_013324 NP_037456 NM_145071 NP_659508
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}.
Top Pathways	Jak-STAT signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CISH full length protein - ab117057 from Abcam Category Protein Source Wheat germ Species Human

Human CISH full length protein - ab158124 from Abcam Category Protein Source Wheat germ Species Human

Human CISH protein fragment - ab158125 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human CISH/CIS-1 Protein - H00001154-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CISH/CIS-1 Protein - H00001154-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CISH/CIS-1 Recombinant Protein - H00001154-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CISH peptide - orb217100 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Cish Blocking Peptide - 33R-7890 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

G18 Blocking Peptide - abx062431 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

CIS1 - H00001154-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CIS1 - H00001154-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CIS1 - H00001154-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CIS1 - H00001154-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CIS1 - H00001154-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CIS1 - H00001154-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CIS1 - H00001154-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CISH fusion protein - Ag4038 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CISH, GST-tagged - CISH-11255H from Creative Biomart Category Protein Source E.coli Species Human

G18 Blocking Peptide - CBP1237 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig

Recombinant Human Cytokine-inducible SH2-containing protein(CISH) - CSB-YP885721HU CSB-EP885721HU CSB-BP885721HU CSB-MP885721HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Cytokine Inducible SH2 Containing Protein (CISH) - RPC383Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cytokine Inducible SH2 Containing Protein (CISH) - RPC383Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cytokine Inducible SH2 Containing Protein (CISH) - RPC383Hu01 from Cloud-clone Category Protein Source E.coli Species Human

CISH/CIS-1 Recombinant Protein Antigen - NBP2-38474PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CISH Peptide, Human - M34GP03186H from Creative Peptides Category Peptide Source Synthetic. Species Human

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