CISH

Gene Symbol CISH
Entrez Gene 1154
Alt Symbol BACTS2, CIS, CIS-1, G18, SOCS
Species Human
Gene Type protein-coding
Description cytokine inducible SH2-containing protein
Other Description cytokine-inducible SH2-containing protein|cytokine-inducible inhibitor of signaling type 1B|suppressor of cytokine signaling
Swissprots Q9NS38 Q9Y5R1 G5E9R1 B2R9N1 Q9NSE2
Accessions AAQ13420 EAW65127 EAW65128 EAW65129 EAW65130 Q9NSE2 AF035947 AAF97410 AF132297 AAD28471 AK313850 BAG36578 BC031590 AAH31590 BC064354 AAH64354 BF511692 CA435538 D83532 BAA92328 DA957793 XM_011533329 XP_011531631 NM_013324 NP_037456 NM_145071 NP_659508
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway

CISH (D4D9) Rabbit mAb - 8731 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4D9
Western blot analysis of extracts from NK-92 cells, untreated (-) or treated (+) with Human Interleukin-2 (hIL-2) #8907 (10 ng/ml, overnight), or BaF3 cells, untreated (-) or treated (+) with Mouse Interleukin-3 (mIL-3) #8923 (10 ng/ml, 6 hr), using CISH (D4D9) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

CISH (D4C10) Rabbit mAb - 8431 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4C10
Western blot analysis of extracts from NK-92 cells, untreated (-) or treated (+) with Human Interleukin-2 (hIL-2) #8907 (10 ng/ml, overnight), using CISH (D4C10) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

CIS (H-80) - sc-15344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CIS (H-80): sc-15344. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

CIS (D-8) - sc-74581 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIS (D-8): sc-74581. Western blot analysis of CIS expression in non-transfected (A) and human CIS transfected (B) CHO whole cell lysates.

CIS (F-9) - sc-166326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIS (F-9): sc-166326. Western blot analysis of CIS expression in non-transfected: sc-117752 (A) and mouse CIS transfected: sc-119271 (B) 293T whole cell lysates.

CIS (C-20) - sc-1528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CIS (D-2) - sc-166363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CIS (D-2): sc-166363. Western blot analysis of CIS expression in non-transfected: sc-117752 (A) and mouse CIS transfected: sc-119271 (B) 293T whole cell lysates.

CIS (N-19) - sc-1529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIS (N-19): sc-1529. Western blot analysis of CIS expression in non-transfected: sc-117752 (A) and mouse CIS transfected: sc-119271 (B) 293T whole cell lysates.

Anti-CISH antibody - ab5923 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH antibody - ab88383 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CISH antibody (ab88383) at 1 µg/ml + human spleen tissue lysate at 50 µg

Anti-CISH antibody - ab192383 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CISH antibody (ab192383)Lane 1 : MCF-7 whole cell lysateLane 2 : Mouse brain lysateLane 3 : PC12 whole cell lysate

Anti-CISH / SOCS Antibody - LS-C22231 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH / SOCS Antibody (C-Terminus) - LS-C33553 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH / SOCS Antibody (aa1-258) - LS-C128171 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CISH / SOCS Antibody - LS-C309917 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH / SOCS Antibody (aa78-127) - LS-C135290 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CISH antibody LS-C135290 Western blot of Mouse Heart lysate.

Anti-CISH / SOCS Antibody - LS-C340924 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH / SOCS Antibody - LS-C335649 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CISH antibody.

Anti-CISH / SOCS Antibody (aa241-258) - LS-C312931 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CISH / SOCS antibody. IHC(P): Human Lung Cancer Tissue.

CISH/CIS-1 Antibody - NBP1-30943 from Novus Biologicals

Prices $129.00, $329.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CISH/CIS-1 Antibody [NBP1-30943] - A. 30 ug PC-12 whole cell lysate/extract B. 30 ug Rat2 whole cell lysate/extract 12 % SDS-PAGE

CISH/CIS-1 Antibody - AF3194 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Nalm‑6 human Pre‑B acute lymphocytic leukemia cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human CIS-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3194) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for CIS-1 at approximately 35‑40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

CISH/CIS-1 Antibody - H00001154-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CISH/CIS-1 Antibody [H00001154-B01P] - Analysis of CISH expression in human spleen.

CISH/CIS-1 Antibody - NBP2-38474 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: CISH/CIS-1 Antibody [NBP2-38474] - Immunofluorescent staining of human cell line U-2 OS shows localization to microtubules & cytokinetic bridge.

CISH/CIS-1 Antibody - H00001154-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CISH antibody produced in rabbit - SAB1400050 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-CISH, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1400050</B>: Antibody concentration: 0.1 ~ 5.0 μg/mL. Specific band of ~28.7 kDa using CISH transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.
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