| Gene Symbol | CISH |
|---|---|
| Entrez Gene | 1154 |
| Alt Symbol | BACTS2, CIS, CIS-1, G18, SOCS |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytokine inducible SH2-containing protein |
| Other Description | cytokine-inducible SH2-containing protein|cytokine-inducible inhibitor of signaling type 1B|suppressor of cytokine signaling |
| Swissprots | Q9NS38 Q9Y5R1 G5E9R1 B2R9N1 Q9NSE2 |
| Accessions | AAQ13420 EAW65127 EAW65128 EAW65129 EAW65130 Q9NSE2 AF035947 AAF97410 AF132297 AAD28471 AK313850 BAG36578 BC031590 AAH31590 BC064354 AAH64354 BF511692 CA435538 D83532 BAA92328 DA957793 XM_011533329 XP_011531631 NM_013324 NP_037456 NM_145071 NP_659508 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}. |
| Top Pathways | Jak-STAT signaling pathway, Prolactin signaling pathway |
CIS CRISPR/Cas9 KO Plasmid (h) - sc-402619 from Santa Cruz Biotechnology
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CIS HDR Plasmid (h) - sc-402619-HDR from Santa Cruz Biotechnology
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CIS Double Nickase Plasmid (h) - sc-402619-NIC from Santa Cruz Biotechnology
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CIS Double Nickase Plasmid (h2) - sc-402619-NIC-2 from Santa Cruz Biotechnology
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CIS CRISPR Activation Plasmid (h) - sc-402619-ACT from Santa Cruz Biotechnology
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CIS CRISPR Activation Plasmid (h2) - sc-402619-ACT-2 from Santa Cruz Biotechnology
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CIS Lentiviral Activation Particles (h) - sc-402619-LAC from Santa Cruz Biotechnology
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CIS Lentiviral Activation Particles (h2) - sc-402619-LAC-2 from Santa Cruz Biotechnology
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CIS siRNA (h) - sc-43685 from Santa Cruz Biotechnology
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CIS shRNA Plasmid (h) - sc-43685-SH from Santa Cruz Biotechnology
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CIS shRNA (h) Lentiviral Particles - sc-43685-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6143 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6143 from Sigma-Aldrich
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CISH siRNA (Human) - CRH0828 from Cohesion Biosciences
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CISH - MBS8232244 from MyBioSource
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shRNA set against Human CISH (NM_145071.2) - SHH264217 from Creative biogene
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Human CISH siRNA - orb261330 from Biorbyt
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CISH shRNA Plasmid (Human) - CHH0828 from Cohesion Biosciences
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CISH miRNA 3'UTR clone - MiUTR3H-04991 from Creative biogene
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CISH miRNA 3'UTR clone - MiUTR3H-04992 from Creative biogene
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