| Gene Symbol |
CHML
|
| Entrez Gene |
1122
|
| Alt Symbol |
REP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
choroideremia-like (Rab escort protein 2)
|
| Other Description |
choroideraemia-like protein|choroideremia-like protein|rab proteins geranylgeranyltransferase component A 2
|
| Swissprots |
B2RAB9 P26374 Q9H1Y4 Q17RE0
|
| Accessions |
AAO15716 EAW70100 P26374 AK000933 AK023423 AK314125 BAG36816 BC117360 AAI17361 BG108374 BI088411 BM457359 BM470658 BM557064 BM763291 BM806625 BQ775652 BU187416 BU195066 CB160778 CN415289 DA612361 X64728 CAA45979 NM_001821 NP_001812
|
| Function |
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. {ECO:0000269|PubMed:12356470, ECO:0000269|PubMed:15186776, ECO:0000269|PubMed:8294464}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:12356470}.
|