Gene Symbol | CHML |
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Entrez Gene | 1122 |
Alt Symbol | REP2 |
Species | Human |
Gene Type | protein-coding |
Description | choroideremia-like (Rab escort protein 2) |
Other Description | choroideraemia-like protein|choroideremia-like protein|rab proteins geranylgeranyltransferase component A 2 |
Swissprots | B2RAB9 P26374 Q9H1Y4 Q17RE0 |
Accessions | AAO15716 EAW70100 P26374 AK000933 AK023423 AK314125 BAG36816 BC117360 AAI17361 BG108374 BI088411 BM457359 BM470658 BM557064 BM763291 BM806625 BQ775652 BU187416 BU195066 CB160778 CN415289 DA612361 X64728 CAA45979 NM_001821 NP_001812 |
Function | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. {ECO:0000269|PubMed:12356470, ECO:0000269|PubMed:15186776, ECO:0000269|PubMed:8294464}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:12356470}. |
REP-2 CRISPR/Cas9 KO Plasmid (h) - sc-417782 from Santa Cruz Biotechnology
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REP-2 HDR Plasmid (h) - sc-417782-HDR from Santa Cruz Biotechnology
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REP-2 Double Nickase Plasmid (h) - sc-417782-NIC from Santa Cruz Biotechnology
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REP-2 Double Nickase Plasmid (h2) - sc-417782-NIC-2 from Santa Cruz Biotechnology
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REP-2 CRISPR Activation Plasmid (h) - sc-417782-ACT from Santa Cruz Biotechnology
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REP-2 CRISPR Activation Plasmid (h2) - sc-417782-ACT-2 from Santa Cruz Biotechnology
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REP-2 Lentiviral Activation Particles (h) - sc-417782-LAC from Santa Cruz Biotechnology
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REP-2 Lentiviral Activation Particles (h2) - sc-417782-LAC-2 from Santa Cruz Biotechnology
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REP-2 siRNA (h) - sc-41806 from Santa Cruz Biotechnology
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REP-2 shRNA Plasmid (h) - sc-41806-SH from Santa Cruz Biotechnology
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REP-2 shRNA (h) Lentiviral Particles - sc-41806-V from Santa Cruz Biotechnology
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CHML RNAi - H00001122-R01 from Novus Biologicals
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MISSION® esiRNA - EHU104001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6067 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6067 from Sigma-Aldrich
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CHML siRNA (Human) - CRH0802 from Cohesion Biosciences
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CHML - MBS8224551 from MyBioSource
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shRNA set against Human CHML (NM_001821.3) - SHH263153 from Creative biogene
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shRNA set against Human CHML(NM_001821.3) - SHG175339 from Creative biogene
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Human CHML siRNA - orb261304 from Biorbyt
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CHML shRNA Plasmid (Human) - CHH0802 from Cohesion Biosciences
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CHML miRNA 3'UTR clone - MiUTR1H-02123 from Creative biogene
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