HSPA5

Gene Symbol HSPA5
Entrez Gene 3309
Alt Symbol BIP, GRP78, HEL-S-89n, MIF2
Species Human
Gene Type protein-coding
Description heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Other Description 78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|epididymis secretory sperm binding protein Li 89n|immunoglobulin heavy chain-binding protein
Swissprots Q9UK02 Q9NPF1 Q2EF78 P11021 B0QZ61
Accessions AAA52614 ABD04090 CAA42595 CAK18759 EAW87620 EAW87621 P11021 AA433933 AF188611 AAF13605 AF216292 AAF42836 AJ271729 CAB71335 AK129617 AK293604 BAG57068 BC020235 AAH20235 DA549454 DQ892173 ABM83099 DQ895368 ABM86294 EU794617 ACJ13671 X87949 CAA61201 NM_005347 NP_005338
Function Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. {ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668}.
Subcellular Location Endoplasmic reticulum lumen. Melanosome. Cytoplasm {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Protein export, Prion diseases, Protein processing in endoplasmic reticulum, Thyroid hormone synthesis, Antigen processing and presentation

BiP (C50B12) Rabbit mAb (PE Conjugate) - 14464 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C50B12
Flow cytometric analysis of A-204 cells using BiP (C50B12) Rabbit mAb (PE Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (PE Conjugate) #5742 (blue).

BiP (C50B12) Rabbit mAb - 3177 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C50B12
Western blot analysis of extracts from various cell lines using BiP (C50B12) Rabbit mAb.

BiP Antibody - 3183 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from several cell lines using BiP Antibody.

GRP 78 (76-E6) - sc-13539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
GRP 78 (76-E6): sc-13539. Western blot analysis of GRP 78 expression in untreated (A) and heat shock-induced HeLa (B) whole cell lysates.

GRP 78 (C-20) - sc-1051 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GRP 78 (C-20): sc-1051. Western blot analysis of GRP 78 expression in NIH/3T3 (A), KNRK (B) and HeLa (C) whole cell lysates.

GRP 78 (H-129) - sc-13968 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRP 78 (H-129): sc-13968. Western blot analysis of GRP 78 expression in HeLa whole cell lysate.

GRP 78 (N-20) - sc-1050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GRP 78 (N-20): sc-1050. Western blot analysis of GRP 78 expression in NIH/3T3 (A) and HeLa (B) whole cell lysates.

Anti-GRP78 antibody - ab188878 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GRP78 antibody (ab188878) at 1/1000 dilution + Mouse liver lysate

Anti-GRP78 BiP antibody - ab89789 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
All lanes : Anti-GRP78 BiP antibody (ab89789) at 1 µg/mlLane 1 : CHO-K1 cell lysate Whole Cell LysateLane 2 : Liver (Mouse) Tissue LysateLane 3 : Liver (Rat) Tissue LysateLane 4 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Chicken IgY - H&L (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GRP78 BiP antibody - ab103336 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GRP78 BiP antibody (ab103336) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-GRP78 BiP antibody [10C3] (DyLight® 488) - ab115638 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 10C3
ab115638 at 10µg/ml staining GRP78 in 506 Jurkat cells by Flow cytometry (shown in green). Grey: unstained;Yellow: isotype control.

Anti-GRP78 BiP antibody [4E3] - ab96483 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E3
All lanes : Anti-GRP78 BiP antibody [4E3] (ab96483) at 1/500 dilutionLane 1 : NIH/3T3 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysate

Anti-GRP78 BiP antibody [76-E6] - ab25192 from Abcam

Prices $379.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 76-E6
IHC image of GRP78 BiP staining in XHuman breast fibroadenoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab25192, 10µg/ml, for 15 mins at room temperature. A Goat anti-Rat biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-GRP78 BiP antibody [9E4-2A7-H6] - C-terminal - ab181499 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9E4-2A7-H6
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of colorectal cancer labeling GRP78 with ab181499 at 1/100. Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).

Anti-GRP78 BiP antibody [EPR4040(2)] - ab108613 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4040(2)
All lanes : Anti-GRP78 BiP antibody [EPR4040(2)] (ab108613) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : LnCaP cell lysateLane 3 : ECV-304 cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.

Anti-GRP78 BiP antibody [EPR4041(2)] - ab108615 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4041(2)
All lanes : Anti-GRP78 BiP antibody [EPR4041(2)] (ab108615) at 1/1000 dilutionLane 1 : HeLa cell lysatesLane 2 : NIH/3T3 cell lysatesLane 3 : LnCaP cell lysatesLane 4 : HepG2 cell lysatesSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GRP78 BiP antibody - C-terminal - ab168806 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GRP78 BiP antibody - C-terminal (ab168806) at 1/1000 dilutionLane 1 : A375 cell line lysatesLane 2 : A2058 cell line lysatesLane 3 : Hela cell line lysatesLysates/proteins at 35 µg per lane.

Anti-HSPA5 / GRP78 / BiP Antibody (aa603-617) - LS-C312961 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HSPA5 / GRP78 / BIP antibody. IHC(F): Rat Intestine Tissue.

Anti-HSPA5 / GRP78 / BiP Antibody (aa645-654) IHC-plus™ - LS-B10040 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HSPA5 / GRP78 / BIP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10040 dilution 1:100.

Anti-HSPA5 / GRP78 / BiP Antibody (clone 6H4.2G7, SA) - LS-C232061 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H4.2G7

Anti-HSPA5 / GRP78 / BiP Antibody (aa548-587, APC) - LS-C258946 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HSPA5 / GRP78 / BiP Antibody (aa548-587, AP) - LS-C258945 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HSPA5 / GRP78 / BiP Antibody (aa548-587, PE) - LS-C258949 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HSPA5 / GRP78 / BiP Antibody (aa270-300, APC) - LS-C258948 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HSPA5 / GRP78 / BiP Antibody (aa270-300, PE) - LS-C258954 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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