FOXP3

Gene Symbol FOXP3
Entrez Gene 50943
Alt Symbol AIID, DIETER, IPEX, JM2, PIDX, XPID
Species Human
Gene Type protein-coding
Description forkhead box P3
Other Description FOXP3delta7|forkhead box protein P3|immune dysregulation, polyendocrinopathy, enteropathy, X-linked|immunodeficiency, polyendocrinopathy, enteropathy, X-linked|scurfin
Swissprots Q14DD8 O60827 Q9BZS1 Q4ZH51 B9UN80 B7ZLG0 A5HJT1
Accessions CAY55968 CCF77062 CDH61704 EAW50671 EAW50672 EAW50673 Q9BZS1 AF277993 AAG53607 AJ005891 CAA06748 AK292052 BAF84741 AK299988 BAG61809 BC111853 AAI11854 BC113401 AAI13402 BC113403 AAI13404 BC143785 AAI43786 BC143786 AAI43787 BQ184335 DB342786 DQ010327 AAY27088 EF534714 ABQ15210 EU855812 ACJ46653 HQ258232 ADR82986 XM_006724533 XP_006724596 XM_011543915 XP_011542217 XM_011543916 XP_011542218 XM_011543917 XP_011542219 XM_011543918 XP_011542220 XM_011543919 XP_011542221 NM_001114377 NP_001107849 NM_014009 NP_054728
Function Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:22678915, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:23973223}. Cytoplasm {ECO:0000269|PubMed:22678915}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:22678915}.
Top Pathways Inflammatory bowel disease (IBD)

Human FOXP3 ELISA Kit (Sandwich ELISA) - LS-F5047 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.45 ng/ml
Range 0.313-20 ng/ml

Mouse FOXP3 ELISA Kit (Sandwich ELISA) - LS-F5824 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.117 ng/ml
Range 0.313-20 ng/ml

Rat FOXP3 ELISA Kit (Sandwich ELISA) - LS-F8671 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.115 ng/ml
Range 0.313-20 ng/ml

Human FOXP3 ELISA Kit (Sandwich ELISA) - LS-F11488 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312 ng/ml
Range 0.313-20 ng/ml

Mouse FOXP3 ELISA Kit (Sandwich ELISA) - LS-F11489 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.25
Range 0.313-20 ng/ml

FoxP3 Flow Assay Kit - NBP2-29484 from Novus Biologicals

Category Flow Assay
Prices $399.00
Sizes 1 kit
Flow Cytometry: FOXP3 Flow Assay Kit [NBP2-29484] - Human PBMCs, stimulated with anti-hCD3 were stained with anti-hCD4 FITC and anti-hCD25 PE, followed by fixation, permeabilization, and staining using anti-FOXP3 APC. CD4+ cells were gated and read for hCD25 PE against either APC isotype control (left) or FOXP3 APC (right).

FoxP3 Flow Assay Kit - NBP2-29483 from Novus Biologicals

Category Flow Assay
Prices $399.00
Sizes 1 kit
Flow Cytometry: FOXP3 Flow Assay Kit [NBP2-29483] - Human PBMCs, stimulated with anti-hCD3 were stained with anti-hCD4 FITC and anti-hCD25 APC, followed by fixation, permeabilization, and staining using anti-FOXP3 PE. CD4+ cells were gated and read for hCD25 APC against either PE isotype control (left) or FOXP3 PE (right).

Human FOXP3 ELISA Kit - abx151582 from Abbexa

Category ELISA Kit
Sensitivity 0.119 ng/ml
Range 0.313 ng/ml - 20 ng/ml

Forkhead box P3 (FoxP3), Human, ELISA Kit - CSB-E14249h from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Forkhead Box Protein P3 (FOXP3), Human, ELISA Kit - SEB877Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 0.119ng/mL
Range 0.312-20ng/mL

Forkhead box protein P3, FOXP3, Human, ELISA Kit - E1877h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.312-20 ng/mL

Forkhead Box Protein P3, FOXP3, Human, ELISA Kit - E-EL-H1104 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Forkhead Box Protein P3, FOXP3, Mouse, ELISA Kit - E-EL-M0513 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Forkhead Box Protein P3, FOXP3, Rabbit, ELISA Kit - E-EL-RB1122 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Forkhead Box Protein P3, FOXP3, Chicken, ELISA Kit - E-EL-Ch1700 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Forkhead Box Protein P3, FOXP3, Porcine, ELISA Kit - E-EL-P0472 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Forkhead Box Protein P3, FOXP3, Guinea Pig, ELISA Kit - E-EL-GP0647 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Forkhead Box Protein P3, FOXP3, Monkey, ELISA Kit - E-EL-MK0095 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

FOXP3 (Human) IP-WB Antibody Pair - H00050943-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Alexa Fluor® 488 anti-human FOXP3 Flow Kit - 320118 from Biolegend

Category Flow Assay
Prices $295.00
Sizes 25 tests
Human peripheral blood lymphocytes surface stained with CD4 APC and then intracellular stained with 206D Alexa Fluor® 488 by using Alexa Fluor® 488 anti-human FOXP3 flow kit. Quadrant markers were set based on the staining with Alexa Fluor® 488 mIgG1, κ isotype control

Alexa Fluor® 647 anti-human FOXP3 Flow Kit - 320119 from Biolegend

Category Flow Assay
Prices $295.00
Sizes 25 tests
Human peripheral blood lymphocytes were surface stained with CD4 PerCP and then intracellularly stained with 206D Alexa Fluor® 647 by using Alexa Fluor® 647 anti-human FOXP3 Flow Kit. Quadrant markers were set based on the staining of mouse IgG1, κ Alexa Fluor® 647 isotype control.

PE anti-human FOXP3 Flow Kit - 320117 from Biolegend

Category Flow Assay
Prices $325.00
Sizes 25 tests
Human peripheral blood lymphocytes surface stained with CD4 FITC and then intracellular stained with 206D PE by using PE anti-human FOXP3 Flow Kit. Quadrant markers were set based on the staining of PE mIgG1, κ isotype control.
Human peripheral blood was stained with Rapid Human Treg ID Kit. Dot plots are gated on CD3+ (top) or CD3+CD4+ cells (bottom).

One Step Staining Human Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD25 PE/CD4 PerCP) - 320121 from Biolegend

Category Flow Assay
Prices $500.00
Sizes 25 tests

Human Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD4 PE-Cy5/CD25 PE) - 320401 from Biolegend

Category Flow Assay
Prices $450.00
Sizes 25 tests
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