| Gene Symbol | MYO1C |
|---|---|
| Entrez Gene | 4641 |
| Alt Symbol | MMI-beta, MMIb, NMI, myr2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin IC |
| Other Description | myosin I beta|myosin-I beta|myosin-Ic|nuclear myosin I|unconventional myosin-Ic |
| Swissprots | Q6NVJ7 Q86Y95 Q4LE56 O00159 |
| Accessions | EAW90619 EAW90620 O00159 AB210015 BAE06097 AI220881 AK172742 AK292910 BAF85599 AK295761 BAH12181 AK304782 BAH14256 BC044891 AAH44891 BC068013 AAH68013 BC127784 AAI27785 BP255642 BP284965 CA422782 CD050346 CN313279 DB241937 X98507 CAA67131 NM_001080779 NP_001074248 NM_001080950 NP_001074419 NM_033375 NP_203693 |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}. |
| Subcellular Location | Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. {ECO:0000250}. |