TEAD2

Gene Symbol TEAD2
Entrez Gene 8463
Alt Symbol ETF, TEAD-2, TEF-4, TEF4
Species Human
Gene Type protein-coding
Description TEA domain family member 2
Other Description transcriptional enhancer factor TEF-4
Swissprots Q96IG3 B4DTJ6 M0R1T9 Q15562 Q8NA25
Accessions EAW52469 EAW52470 EAW52471 EAW52472 EAW52473 Q15562 AK093236 BAC04104 AK290736 BAF83425 AK300241 BAG62008 AL832240 BC007556 AAH07556 BC018803 BC051301 AAH51301 BG334109 DQ893163 ABM84089 DQ896460 ABM87459 X94440 CAA64214 XM_005259334 XP_005259391 XM_006723424 XP_006723487 XM_006723428 XP_006723491 XM_006723429 XP_006723492 XM_011527398 XP_011525700 XM_011527399 XP_011525701 XM_011527400 XP_011525702 XM_011527401 XP_011525703 XM_011527402 XP_011525704 XM_011527403 XP_011525705 XM_011527404 XP_011525706 XM_011527405 XP_011525707 XM_011527406 XP_011525708 NM_001256658 NP_001243587 NM_001256659 NP_001243588 NM_001256660 NP_001243589 NM_001256661 NP_001243590 NM_001256662 NP_001243591 NM_003598 NP_003589
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Subcellular Location Nucleus.
Top Pathways Hippo signaling pathway

TEAD2 Antibody - 8870 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells transfected with a construct expressing either Myc/DDK-tagged full-length human TEAD1 (hTEAD1-Myc/DDK;+), Myc/DDK-tagged full-length human TEAD2 (hTEAD2-Myc/DDK;+), Myc/DDK-tagged full-length human TEAD3 (hTEAD3-Myc/DDK;+), or Myc/DDK-tagged full-length human TEAD4 (hTEAD4-Myc/DDK;+), using TEAD1 (D9X2L) Rabbit mAb #12292 (A), TEAD2 Antibody #8870 (B), TEAD3 Antibody (C), or Pan-TEAD (D3F7L) Rabbit mAb #13295 (D).

TEF-4 (H-50) - sc-67115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TEF-4 (H-50): sc-67115. Western blot analysis of TEF-4 expression in non-transfected: sc-117752 (A) and human TEF-4 transfected: sc-176211 (B) 293T whole cell lysates.

TEF-4 (I-20) - sc-32427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TEF-4 (A-16) - sc-32428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TEF-4 (404C5a) - sc-81397 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TEF-4 (404C5a): sc-81397 Western Blot analysis of human recombinant TEF-4 fusion protein.

Anti-TEA domain family member 2 antibody - ab83670 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TEA domain family member 2 antibody (ab83670) at 1 µg/ml + Human fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TEA domain family member 2 antibody - ab196669 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling TEA domain family member 2 with ab196669 at 1/50 dilution (left) and synthesized peptide (right).

Anti-TEA domain family member 2 antibody - ab92279 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-TEA domain family member 2 antibody (ab92279) at 1 µg/ml + Human ileum lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-TEA domain family member 2 antibody - ab123276 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TEA domain family member 2 antibody (ab123276) at 1/100 dilution + Human placenta tissue lysates at 35 µgdeveloped using the ECL technique

Anti-TEA domain family member 2 antibody - ab172233 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-TEA domain family member 2 antibody (ab172233) at 1/500 dilutionLane 1 : TEA domain family member 2-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-TEA domain family member 2 antibody - ab91049 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TEA domain family member 2 antibody (ab91049) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TEA domain family member 2 antibody [404C5a] - ab54374 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 404C5a
Anti-TEA domain family member 2 antibody [404C5a] (ab54374) + immunizing recombinant protein

Anti-TEAD2 Antibody - LS-C76316 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-TEAD2 Antibody (aa242-253) - LS-C112751 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TEAD2 antibody (1 ug/ml) staining of Human Ileum lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TEAD2 Antibody (clone 2D5) - LS-C198568 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D5

Anti-TEAD2 Antibody (aa266-295, AP) - LS-C271234 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (aa266-295, APC) - LS-C271235 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (N-Terminus) - LS-C101693 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TEAD2 antibody LS-C101693 Western blot of Fetal Brain lysate.

Anti-TEAD2 Antibody (aa323-372) - LS-C109553 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TEAD2 antibody LS-C109553 Western blot of HT1080 cell lysate.

Anti-TEAD2 Antibody (aa266-295, Biotin) - LS-C271236 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (aa266-295, FITC) - LS-C271237 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (aa266-295, Azide-free, HRP) - LS-C271238 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (aa71-120) - LS-C119063 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using TEAD2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-TEAD2 Antibody (aa266-295, PE) - LS-C271240 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TEAD2 Antibody (aa266-295) - LS-C325651 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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