TEAD2

Gene Symbol TEAD2
Entrez Gene 8463
Alt Symbol ETF, TEAD-2, TEF-4, TEF4
Species Human
Gene Type protein-coding
Description TEA domain family member 2
Other Description transcriptional enhancer factor TEF-4
Swissprots Q96IG3 B4DTJ6 M0R1T9 Q15562 Q8NA25
Accessions EAW52469 EAW52470 EAW52471 EAW52472 EAW52473 Q15562 AK093236 BAC04104 AK290736 BAF83425 AK300241 BAG62008 AL832240 BC007556 AAH07556 BC018803 BC051301 AAH51301 BG334109 DQ893163 ABM84089 DQ896460 ABM87459 X94440 CAA64214 XM_005259334 XP_005259391 XM_006723424 XP_006723487 XM_006723428 XP_006723491 XM_006723429 XP_006723492 XM_011527398 XP_011525700 XM_011527399 XP_011525701 XM_011527400 XP_011525702 XM_011527401 XP_011525703 XM_011527402 XP_011525704 XM_011527403 XP_011525705 XM_011527404 XP_011525706 XM_011527405 XP_011525707 XM_011527406 XP_011525708 NM_001256658 NP_001243587 NM_001256659 NP_001243588 NM_001256660 NP_001243589 NM_001256661 NP_001243590 NM_001256662 NP_001243591 NM_003598 NP_003589
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Subcellular Location Nucleus.
Top Pathways Hippo signaling pathway

TEAD2-Over-expression-Lysate - LY13424a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TEAD2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the gene

TEAD2 Overexpression Lysate (Denatured) - H00008463-T03 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human TEAD2 Knockdown Stable Cell Line - CSC-DC015770 from Creative biogene

Category Cell Line
Species Human
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