| Gene Symbol | TEAD2 |
|---|---|
| Entrez Gene | 8463 |
| Alt Symbol | ETF, TEAD-2, TEF-4, TEF4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TEA domain family member 2 |
| Other Description | transcriptional enhancer factor TEF-4 |
| Swissprots | Q96IG3 B4DTJ6 M0R1T9 Q15562 Q8NA25 |
| Accessions | EAW52469 EAW52470 EAW52471 EAW52472 EAW52473 Q15562 AK093236 BAC04104 AK290736 BAF83425 AK300241 BAG62008 AL832240 BC007556 AAH07556 BC018803 BC051301 AAH51301 BG334109 DQ893163 ABM84089 DQ896460 ABM87459 X94440 CAA64214 XM_005259334 XP_005259391 XM_006723424 XP_006723487 XM_006723428 XP_006723491 XM_006723429 XP_006723492 XM_011527398 XP_011525700 XM_011527399 XP_011525701 XM_011527400 XP_011525702 XM_011527401 XP_011525703 XM_011527402 XP_011525704 XM_011527403 XP_011525705 XM_011527404 XP_011525706 XM_011527405 XP_011525707 XM_011527406 XP_011525708 NM_001256658 NP_001243587 NM_001256659 NP_001243588 NM_001256660 NP_001243589 NM_001256661 NP_001243590 NM_001256662 NP_001243591 NM_003598 NP_003589 |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Hippo signaling pathway |
Human-TEAD2-cDNA-Clone - DC07850 from Abgent, a WuXi AppTec company
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TEAD2 - MBS1276856 from MyBioSource
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human TEAD2 ORF clone (NM_003598.1) - CDCH090108 from Creative biogene
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Human TEAD2 ORF Clone (BC007556) - CDCS410107 from Creative biogene
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Human TEAD2 ORF Clone (BC051301) - CDCS410108 from Creative biogene
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Human TEAD2 cDNA Clone(NM_003598.1) - CDFH019419 from Creative biogene
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