CXCR2
| Gene Symbol | CXCR2 |
|---|---|
| Entrez Gene | 3579 |
| Alt Symbol | CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-X-C motif) receptor 2 |
| Other Description | C-X-C chemokine receptor type 2|CXC-R2|CXCR-2|CXCR2 gene for IL8 receptor type B|GRO/MGSA receptor|IL-8 receptor type 2|IL-8R B|chemokine (CXC) receptor 2|high affinity interleukin-8 receptor B|interleukin 8 receptor B|interleukin 8 receptor type 2|interleukin 8 receptor, beta|interleukin-8 receptor type B |
| Swissprots | P25025 Q8IUZ1 Q9P2T6 Q9P2T7 |
| Accessions | AAA15417 AAB24742 AAB60656 AAC14460 AAT97985 AAY24026 BAA92295 BAA92296 CBX54347 EAW70589 P25025 AJ710879 AK290906 BAF83595 AK312664 BAG35546 BC037961 AAH37961 DA670033 DA674925 DQ893661 ABM84587 DQ895671 ABM86597 L19593 AAB59437 M73969 AAA83148 M94582 AAA36108 U11872 AAA64380 U11873 AAA64381 U11874 AAA64382 U11875 AAA64383 U11876 AAA64384 U11877 AAA64385 U11878 AAA64386 XM_005246530 XP_005246587 NM_001168298 NP_001161770 NM_001557 NP_001548 |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Top Pathways | Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Chemokine signaling pathway |
IL-8RB CRISPR/Cas9 KO Plasmid (h) - sc-401404 from Santa Cruz Biotechnology
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IL-8RB HDR Plasmid (h) - sc-401404-HDR from Santa Cruz Biotechnology
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IL-8RB Double Nickase Plasmid (h) - sc-401404-NIC from Santa Cruz Biotechnology
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IL-8RB Double Nickase Plasmid (h2) - sc-401404-NIC-2 from Santa Cruz Biotechnology
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IL-8RB CRISPR Activation Plasmid (h) - sc-401404-ACT from Santa Cruz Biotechnology
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IL-8RB CRISPR Activation Plasmid (h2) - sc-401404-ACT-2 from Santa Cruz Biotechnology
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IL-8RB Lentiviral Activation Particles (h) - sc-401404-LAC from Santa Cruz Biotechnology
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IL-8RB Lentiviral Activation Particles (h2) - sc-401404-LAC-2 from Santa Cruz Biotechnology
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IL-8RB siRNA (h) - sc-40028 from Santa Cruz Biotechnology
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IL-8RB shRNA Plasmid (h) - sc-40028-SH from Santa Cruz Biotechnology
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IL-8RB shRNA (h) Lentiviral Particles - sc-40028-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6810 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6810 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12634 from Sigma-Aldrich
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CXCR2 siRNA (Human) - CRH2394 from Cohesion Biosciences
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CXCR2/IL-8 RB RNAi - H00003579-R02 from Novus Biologicals
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CXCR2 - MBS8231395 from MyBioSource
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shRNA set against Human CXCR2 (NM_001557.3) - SHH272261 from Creative biogene
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Human CXCR2 siRNA - orb262896 from Biorbyt
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CXCR2 shRNA Plasmid (Human) - CHH2394 from Cohesion Biosciences
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CXCR2 miRNA 3'UTR clone - MiUTR3H-01165 from Creative biogene
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