CXCR2

Gene Symbol CXCR2
Entrez Gene 3579
Alt Symbol CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Species Human
Gene Type protein-coding
Description chemokine (C-X-C motif) receptor 2
Other Description C-X-C chemokine receptor type 2|CXC-R2|CXCR-2|CXCR2 gene for IL8 receptor type B|GRO/MGSA receptor|IL-8 receptor type 2|IL-8R B|chemokine (CXC) receptor 2|high affinity interleukin-8 receptor B|interleukin 8 receptor B|interleukin 8 receptor type 2|interleukin 8 receptor, beta|interleukin-8 receptor type B
Swissprots P25025 Q8IUZ1 Q9P2T6 Q9P2T7
Accessions AAA15417 AAB24742 AAB60656 AAC14460 AAT97985 AAY24026 BAA92295 BAA92296 CBX54347 EAW70589 P25025 AJ710879 AK290906 BAF83595 AK312664 BAG35546 BC037961 AAH37961 DA670033 DA674925 DQ893661 ABM84587 DQ895671 ABM86597 L19593 AAB59437 M73969 AAA83148 M94582 AAA36108 U11872 AAA64380 U11873 AAA64381 U11874 AAA64382 U11875 AAA64383 U11876 AAA64384 U11877 AAA64385 U11878 AAA64386 XM_005246530 XP_005246587 NM_001168298 NP_001161770 NM_001557 NP_001548
Function Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Top Pathways Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Chemokine signaling pathway

IL-8RB (5E8) - sc-32780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-8RB (5E8): sc-32780. Western blot analysis of IL-8RB expression in IL-8RB transfected CHO-K1 cells (A) and non-transfected CHO-K1 (B) cells.

IL-8RB (C-19) - sc-682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-8RB (C-19): sc-682. Western blot analysis of IL-8RB expression in human PBL whole cell lysate.

IL-8RB (E-2) - sc-7304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-8RB (E-2) FITC: sc-7304 FITC. Intracellular FCM analysis of fixed and permeabilized IL-8RB transfected CHO-K1 cells. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

IL-8RB (K-19) - sc-683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-8RB (K-19) PE: sc-683 PE. Intracellular FCM analysis of fixed and permeabilized non-transfected (green line histogram) and IL-8RB transfected (solid orange histogram) CHO-K1 cells. Dotted pink histogram represents the isotype control, normal rabbit IgG: sc-3871.

IL-8RB (S-16) - sc-22661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CXCR2 (phospho S347) antibody - ab61100 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
1/50-1/100 ab61100 staining phosphorilated CXCR2 on human breast carcinoma tissue, in the presence or absence of the immunizing phospopeptide.

Anti-CXCR2 antibody - ab14935 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab14935 staining CXCR2 in Mouse spleen cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde and blocked with 10% serum for 1 hour at room temperature. Samples were incubated with primary antibody (1/200 in PBS) for 1 hour. An Alexa Fluor®555-conjugated Goat anti-rabbit IgG polyclonal (1/500) was used as the secondary antibody.See Abreview

Anti-CXCR2 antibody - ab65968 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CXCR2 antibody (ab65968) at 2 µg/ml + Human colon carcinoma lysate

Anti-CXCR2 antibody - ab21641 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab21641 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab21641, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 4% PFA fixed (10 min) HepG2 and MCF7 cells at 5µg/ml.

Anti-CXCR2 antibody - ab63437 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab63437 at 1/500 - 1/1000 dilution staining CXCR2 in HepG2 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-CXCR2 antibody - ab194657 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CXCR2 antibody [19] - ab24963 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19
Human peripheral blood granulocytes stained with ab24963 (red line). Human whole blood was processed using a modified protocol based on Chow et al, 2005 (PMID: 16080188). In brief, human whole blood was fixed in 4% formaldehyde (methanol-free) for 10 min at 22°C. Red blood cells were then lyzed by the addition of Triton X-100 (final concentration - 0.1%) for 15 min at 37°C. For experimentation, cells were treated with 50% methanol (-20°C) for 15 min at 4°C. Cells were then incubated with the antibody (ab24963, 0.1μg/1x106 cells) for 30 min at 4°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 4°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >30,000 total events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Gating strategy - periphera

Anti-CXCR2 antibody [48311.211] - ab10401 from Abcam

Prices $382.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 48311.211
ab10401 staining CXCR2 in Human PBMC by Flow cytometry.Cells were fixed in formaldehyde. Primary antibody used at a 1/100 dilution and incubated for 1 hour. The secondary antibody used was a FITC conjugated goat anti-mouse IgG.Rabbit IgG isotype control (black)See Abreview

Anti-CXCR2 antibody (FITC) - ab136179 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CXCR2 antibody [MM0222-7J40] - ab89254 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0222-7J40

Anti-CXCR2 Antibody - LS-C8056 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR2 Antibody (PE) - LS-C14720 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR2 Antibody - LS-C26950 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR2 Antibody (RPE) - LS-C43559 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR2 Antibody - LS-C64013 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXCR2 Antibody - LS-C121683 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXCR2 Antibody (aa196-212) - LS-C130225 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXCR2 Antibody - LS-C26949 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Isolated human neutrophils were incubated with 1.0 g anti-human CXCR2 followed by staining with goat F(ab')2 anti-mouse IgG FITC [shaded peak]. Specificity of signal was confirmed by staining the neutrophils with 1.0 g mouse IgG1 isotype control followed by the secondary antibody [unshaded peak]. The data indicate that approximately 98% of the isolated neutrophil population stains positive for this IL-8 receptor (M2 region).

Anti-CXCR2 Antibody (clone 5E8-C7-F10) - LS-C106914 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5E8-C7-F10
Staining of normal human peripheral blood cells 0.25 ug of Purified anti-human CD182 (5E8-C7-F7) (right) followed by PE Donkey F(ab')2 Fragment Anti-Mouse IgG (H+L, Minimal Reactivity to Rat IgG). Cells in the large scatter population were used for analysis.

Anti-CXCR2 Antibody (Internal, Magnetic beads) - LS-C171553 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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