KDM6A

Gene Symbol KDM6A
Entrez Gene 7403
Alt Symbol KABUK2, UTX, bA386N14.2
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 6A
Other Description bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))|histone demethylase UTX|lysine-specific demethylase 6A|ubiquitously transcribed tetratricopeptide repeat protein X-linked|ubiquitously-transcribed TPR gene on the X chromosome
Swissprots Q5JVQ7 Q52LL9 O15550
Accessions AAT86073 EAW59368 O15550 AB208795 BAD92032 AF000992 AAC51839 AF000993 AAC51840 AI364446 AK294456 BAG57692 AK303430 BAG64480 AK304114 BAG65015 AK307691 AL041377 AL831996 CAD89904 BC093868 AAH93868 BC113381 AAI13382 BC143272 AAI43273 BC143275 BC143277 AAI43278 BC143278 AAI43279 BX640694 CAE45817 CR749602 CAH18397 DC381812 DQ062676 AAZ06655 DQ062677 AAZ06656 DQ062678 AAZ06657 EU026283 ABV82614 EU026291 ABV82622 XM_005272656 XP_005272713 XM_005272659 XP_005272716 XM_011543957 XP_011542259 XM_011543958 XP_011542260 XM_011543959 XP_011542261 XM_011543960 XP_011542262 XM_011543961 XP_011542263 XM_011543962 XP_011542264 XM_011543963 XP_011542265 XM_011543964 XP_011542266 XM_011543965 XP_011542267 XM_011543966 XP_011542268 XM_011543967 XP_011542269 XM_011543968 XP_011542270 XM_011543969 XP_011542271 XM_011543970 XP_011542272 XM_011543971 XP_011542273 XM_011543972 XP_011542274 XM_011543973 XP_011542275 XM_011543974 XP_011542276 XM_011543975 XP_011542277 XM_011543976 XP_011542278 XR_949018 NM_001291415 NP_001278344 NM_001291416 NP_001278345 NM_001291417 NP_001278346 NM_001291418 NP_001278347 NM_001291421 NP_001278350 NM_021140 NP_066963 NR_111960
Function Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. {ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529}.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Transcriptional misregulation in cancer

KDM6A/ KDM6B Activity Quantification Assay Kit (Colorimetric) - ab156910 from Abcam

Category Cellular Assay
Prices $391.00, $628.00
Sizes 48 tests, 96 tests
Sensitivity > 10000 ng
Range 1 ng - 20000 ng
Demonstration of high sensitivity of KDM6A/KDM6B activity assay achieved by using KDM6A (UTX) recombinant protein with the KDM6A/KDM6B Activity Quantification Assay Kit (Colorimetric).

KDM6A/KDM6B Activity Quantification Assay Kit (Fluorometric) - ab156911 from Abcam

Category Cellular Assay
Prices $299.00, $546.00
Sizes 48 tests, 96 tests
Sensitivity 10 ng
Demonstration of high sensitivity of KDM6A/KDM6B activity assay achieved by using KDM6A recombinant protein with the  KDM6A/KDM6B Activity Quantification Assay Kit (Fluorometric).

ubiquitously transcribed tetratricopeptide repeat, X chromosome, ELISA Kit - MBS9327158 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.625ng/ml-20ng/ml.

Human KDM6A ELISA Kit - E087613 from Biobool

Category ELISA Kit

Lysine-Specific Demethylase 6A (UTX), ELISA Kit - MBS9376907 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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