KDM6A

Gene Symbol	KDM6A
Entrez Gene	7403
Alt Symbol	KABUK2, UTX, bA386N14.2
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific demethylase 6A
Other Description	bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))|histone demethylase UTX|lysine-specific demethylase 6A|ubiquitously transcribed tetratricopeptide repeat protein X-linked|ubiquitously-transcribed TPR gene on the X chromosome
Swissprots	Q5JVQ7 Q52LL9 O15550
Accessions	AAT86073 EAW59368 O15550 AB208795 BAD92032 AF000992 AAC51839 AF000993 AAC51840 AI364446 AK294456 BAG57692 AK303430 BAG64480 AK304114 BAG65015 AK307691 AL041377 AL831996 CAD89904 BC093868 AAH93868 BC113381 AAI13382 BC143272 AAI43273 BC143275 BC143277 AAI43278 BC143278 AAI43279 BX640694 CAE45817 CR749602 CAH18397 DC381812 DQ062676 AAZ06655 DQ062677 AAZ06656 DQ062678 AAZ06657 EU026283 ABV82614 EU026291 ABV82622 XM_005272656 XP_005272713 XM_005272659 XP_005272716 XM_011543957 XP_011542259 XM_011543958 XP_011542260 XM_011543959 XP_011542261 XM_011543960 XP_011542262 XM_011543961 XP_011542263 XM_011543962 XP_011542264 XM_011543963 XP_011542265 XM_011543964 XP_011542266 XM_011543965 XP_011542267 XM_011543966 XP_011542268 XM_011543967 XP_011542269 XM_011543968 XP_011542270 XM_011543969 XP_011542271 XM_011543970 XP_011542272 XM_011543971 XP_011542273 XM_011543972 XP_011542274 XM_011543973 XP_011542275 XM_011543974 XP_011542276 XM_011543975 XP_011542277 XM_011543976 XP_011542278 XR_949018 NM_001291415 NP_001278344 NM_001291416 NP_001278345 NM_001291417 NP_001278346 NM_001291418 NP_001278347 NM_001291421 NP_001278350 NM_021140 NP_066963 NR_111960
Function	Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. {ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KDM6A / UTX full length protein - ab196429 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human KDM6A / UTX peptide - ab36937 from Abcam Category Peptide

Human KDM6A / UTX protein fragment - ab159790 from Abcam Category Protein Source Wheat germ Species Human

KDM6A / UTX Antibody Blocking Peptide - LS-E14276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDM6A / UTX Antibody Blocking Peptide - LS-E14277 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDM6A / UTX Antibody Blocking Peptide - LS-E11830 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KDM6A Protein - H00007403-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Utx Blocking Peptide - 33R-10306 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KDM6A / UTX - H00007403-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KDM6A / UTX - H00007403-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UTX fusion protein - ag20018 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant UTX / KDM6A protein - 31460 from ActiveMotif Category Protein Prices $395.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human KDM6A protein, FLAG-tagged - KDM6A-84H from Creative Biomart Category Protein Source Insect Cells Species Human

Recombinant Human Lysine-specific demethylase 6A(KDM6A) ,partial - CSB-YP025774HU CSB-EP025774HU CSB-BP025774HU CSB-MP025774HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KDM6A Protein - abx163295 from Abbexa Category Protein Species Human, Mouse

KDM6A / UTX - TP310861 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KDM6A Recombinant Protein Antigen - NBP1-80628PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KDM6A-Blocking-Peptide-Center - BP21261c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KDM6A Peptide, Human - M34GP08054H from Creative Peptides Category Peptide Source Synthetic. Species Human

UTX protein (1264-1273) - ta-114 from Creative Peptides Category Protein Source Homo sapiens (human)

Lysine-specific demethylase 6A (KDM6A), partial, Recombinant Protein - MBS1223067 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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