KDM6A

Gene Symbol KDM6A
Entrez Gene 7403
Alt Symbol KABUK2, UTX, bA386N14.2
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 6A
Other Description bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))|histone demethylase UTX|lysine-specific demethylase 6A|ubiquitously transcribed tetratricopeptide repeat protein X-linked|ubiquitously-transcribed TPR gene on the X chromosome
Swissprots Q5JVQ7 Q52LL9 O15550
Accessions AAT86073 EAW59368 O15550 AB208795 BAD92032 AF000992 AAC51839 AF000993 AAC51840 AI364446 AK294456 BAG57692 AK303430 BAG64480 AK304114 BAG65015 AK307691 AL041377 AL831996 CAD89904 BC093868 AAH93868 BC113381 AAI13382 BC143272 AAI43273 BC143275 BC143277 AAI43278 BC143278 AAI43279 BX640694 CAE45817 CR749602 CAH18397 DC381812 DQ062676 AAZ06655 DQ062677 AAZ06656 DQ062678 AAZ06657 EU026283 ABV82614 EU026291 ABV82622 XM_005272656 XP_005272713 XM_005272659 XP_005272716 XM_011543957 XP_011542259 XM_011543958 XP_011542260 XM_011543959 XP_011542261 XM_011543960 XP_011542262 XM_011543961 XP_011542263 XM_011543962 XP_011542264 XM_011543963 XP_011542265 XM_011543964 XP_011542266 XM_011543965 XP_011542267 XM_011543966 XP_011542268 XM_011543967 XP_011542269 XM_011543968 XP_011542270 XM_011543969 XP_011542271 XM_011543970 XP_011542272 XM_011543971 XP_011542273 XM_011543972 XP_011542274 XM_011543973 XP_011542275 XM_011543974 XP_011542276 XM_011543975 XP_011542277 XM_011543976 XP_011542278 XR_949018 NM_001291415 NP_001278344 NM_001291416 NP_001278345 NM_001291417 NP_001278346 NM_001291418 NP_001278347 NM_001291421 NP_001278350 NM_021140 NP_066963 NR_111960
Function Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. {ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529}.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Transcriptional misregulation in cancer

UTX (P-18) - sc-79332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UTX (T-17) - sc-79334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UTX (T-17): sc-79334. Western blot analysis of UTX expression in K-562 (A) and Hep G2 (B) whole cell lysates.

UTX/Y (H-300) - sc-292326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-KDM6A / UTX antibody - ab36938 from Abcam

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM6A / UTX antibody (ab36938) at 1 µg/mlLane 1 : Whole NIH3T3 cell lysate (no shRNA)Lane 2 : Whole NIH3T3 cell lysate (Control shRNA)Lane 3 : Whole NIH3T3 cell lysate (Utx shRNA)Lysates/proteins at 20 µg per lane.SecondaryHRP-conjugated Goat anti-Rabbit polyclonaldeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KDM6A / UTX antibody [3A2] - ab91231 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A2

Anti-KDM6A / UTX antibody [GT1612] - ab184525 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT1612
All lanes : Anti-KDM6A / UTX antibody [GT1612] (ab184525) at 1/500 dilutionLane 1 : U87-MG whole cell lysateLane 2 : SK-N-SH whole cell lysateLane 3 : IMR32 whole cell lysateLane 4 : SK-N-AS whole cell lysateLysates/proteins at 30 µg per lane.

Anti-KDM6A / UTX Antibody (N-Terminus) - LS-C116898 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KDM6A / UTX antibody LS-C116898 Western blot of HeLa lysate.

Anti-KDM6A / UTX Antibody (clone 4E7) - LS-C198418 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E7
KDM6A monoclonal antibody (M05), clone 4E7. Western Blot analysis of KDM6A expression in HepG2.

Anti-KDM6A / UTX Antibody (C-Terminus) IHC-plus™ - LS-B5648 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KDM6A / UTX antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5648 concentration 5 ug/ml.

Anti-KDM6A / UTX Antibody (aa245-294) IHC-plus™ - LS-B11462 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KDM6A / UTX antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11462 concentration 10 ug/ml.

KDM6A Antibody (4E7.) - H00007403-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E7.
Western Blot: KDM6A Antibody (4E7) [H00007403-M05] - Analysis of KDM6A expression in IMR-32.

KDM6A Antibody - NBP1-80628 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KDM6A Antibody [NBP1-80628] - Analysis in human cell line HEK 293.

Anti-UTX antibody produced in rabbit - SAB2102665 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-UTX: <B>Cat. No.SAB2102665</B>: UTX in MCF7 cell lysate with UTX antibody at 1.0 μg/mL.

ANTI-KDM6A antibody produced in rabbit - HPA002111 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UTX: <B>Cat. No. HPA002111</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenum shows strong nuclear positivity in glandular cells.

Anti-KDM6A antibody produced in rabbit - SAB2702123 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KDM6A: <B>Cat. No. SAB2702123</B>: Immunohistochemical analysis of paraffin-embedded H441 xenograft, using KDM6A antibody at a 1:250 dilution.

UTX antibody - N-terminal region (ARP39482_P050) - ARP39482_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UTX antibody - middle region (ARP39483_P050) - ARP39483_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KDM6A-Antibody-Center - AP21261c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM6A Antibody (Center) at 1:2000 dilution Lane 1: human liver lysates Lane 2: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 154 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

KDM6A antibody [C2C3], C-term - GTX120873 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-KDM6A antibody [C2C3], C-term used in Western blot. GTX120873

KDM6A antibody [GT1612] - GTX630412 from GeneTex

Prices $119.00
Sizes 25 μl
Host Mouse
Clonality Monoclonal
Clone GT1612
Anti-KDM6A antibody [GT1612] used in Western blot. GTX630412

KDM6A antibody [N2C1], Internal - GTX121246 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-KDM6A antibody [N2C1], Internal used in Western blot. GTX121246

KDM6A antibody - orb66980 from Biorbyt

Prices $425.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from human Hela using KDM6A antibody

KDM6A antibody - orb66981 from Biorbyt

Prices $425.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from human Hela using KDM6A antibody

KDM6A antibody pair - orb66982 from Biorbyt

Prices $476.00
Sizes 2x50 μl (Antibody pair)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell extracts from human Hela using KDM6A antibody

Utx antibody - 70R-7989 from Fitzgerald

Prices $375.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Search more